The risk assessment of chemical carcinogens is one major task in toxicology. Even though
exposure has been mitigated effectively during the last decades, low levels of carcinogenic …

This article provides a comprehensive review of hormesis, a dose‐response concept that is
characterized by a low‐dose stimulation and a high‐dose inhibition. The article traces the …

Alkylation lesions in DNA and RNA result from endogenous compounds, environmental
agents and alkylating drugs. Simple methylating agents, eg methylnitrosourea, tobacco …

This article assesses the nature of the dose-response relationship of human tumor cell lines
with a wide range of agents including antineoplastics, toxic substances (ie, environmental …

This is the second of two reports from the International Workshops on Genotoxicity Testing
(IWGT) Working Group on Quantitative Approaches to Genetic Toxicology Risk Assessment …

Objectives This report reviews the carcinogenicity of multi‐walled carbon nanotubes
(MWCNTs) in experimental animals, concentrating on MWNT‐7, a straight fibrous MWCNT …

Recently the idea of hormesis, a biphasic dose–response relationship in which a chemical
exerts opposite effects dependent on the dose, has attracted interest in the field of …

In the deliberations over many years on the question of thresholds for the carcinogenicity of
chemicals, the dominant paradigm has been the linear no-threshold (LNT) model, derived …

Dioxane is a widely used synthetic industrial chemical and its contamination of drinking
water and food is a potential health concern. It induces liver tumors when administered in …

Recent low-dose carcinogenesis studies, including major group projects are reviewed. The
prevailing paradigm is that carcinogens, particularly genotoxic compounds, have no …