Toxoplasma gondii is an exceptionally successful parasite that infects a very broad host
range, including humans, across the globe. The outcome of infection differs remarkably …

Naive CD8+ T cells give rise to cytotoxic T lymphocytes (CTLs), which promote the effective
eradication of viruses and tumours. Although the past decades have seen enormous …

In Toxoplasma gondii, dense granules are known as the storage secretory organelles of the
so-called GRA proteins (for dense granule proteins), which are destined to the …

Upon infection of humans and animals with Toxoplasma gondii, the parasites persist as
intraneuronal cysts that are controlled, but not eliminated by the immune system. In …

Toxoplasma gondii is an obligate intracellular parasite of clinical importance, especially in
immunocompromised patients. Investigations into the immune response to the parasite …

In eutherians, the placenta acts as a barrier and conduit at the maternal-fetal interface.
Syncytiotrophoblasts, the multinucleated cells that cover the placental villous tree surfaces of …

Toxoplasma gondii is an obligate intracellular parasite and the causative agent of
Toxoplasmosis. A key to understanding and treating the disease lies with determining how …

Toxoplasma gondii infection results in co-option and subversion of host cellular signaling
pathways. This process involves discharge of T. gondii effector molecules from parasite …

Adaptive immune responses against antigenically variable viruses and cellular pathogens
are efficient in many cases, but largely limited to the infecting or immunizing strain. A major …

Toxoplasma gondii is responsible for toxoplasmosis, a disease that can be serious when
contracted during pregnancy, but can also be a threat for immunocompromised individuals …