Human mesenchymal stem cells (MSCs) are primary multipotent cells capable of
differentiating into osteocytes, chondrocytes, and adipocytes when stimulated under …

Introduction: Aging is a normal, inevitable, irreversible and progressive process which is
driven by internal and external factors. Oxidative stress, that is the imbalance between …

The stromal component of the tumour microenvironment in primary and metastatic prostate
cancer can influence and promote disease progression. Within the prostatic stroma …

Alveolar epithelial cell (AEC) senescence is implicated in the pathogenesis of idiopathic
pulmonary fibrosis (IPF). Mitochondrial dysfunction including release of mitochondrial DNA …

Aging is the main risk factor for chronic lung diseases (CLDs) including idiopathic pulmonary
fibrosis (IPF) and chronic obstructive pulmonary disease (COPD). Accordingly, hallmarks of …

Hypoxia, a state of insufficient oxygen availability, promotes cellular lactate production.
Lactate levels are increased in lungs from patients with idiopathic pulmonary fibrosis (IPF), a …

Review paper attempts to explain the dynamic aspects of redox signaling in aging through
autophagy, inflammation, and senescence. It begins with ROS source in the cell, then states …

Therapeutically targeting senescent cells seems to be an interesting perspective in treating
chronic lung diseases, which are often associated with human aging. The combination of the …

Senescent cells may have a prominent role in driving inflammation and frailty. The impact of
cellular senescence on frailty varies depending on the assessment tool used, as it is …

Idiopathic pulmonary fibrosis (IPF) is an age-related disease with poor prognosis and limited
therapeutic options. Activation of lung fibroblasts and differentiation to myofibroblasts are the …