Innovations in Next-Generation Sequencing are enabling generation of DNA sequence data
at ever faster rates and at very low cost. For example, the Illumina NovaSeq 6000 sequencer …

The reference genome serves two distinct purposes within the field of genomics. First, it
provides a persistent structure against which findings can be reported, allowing for universal …

Sequence alignment remains a fundamental problem with practical applications ranging
from pattern recognition to computational biology. Traditional algorithms based on dynamic …

Genomics is the critical key to enabling precision medicine, ensuring global food security
and enforcing wildlife conservation. The massive genomic data produced by various …

Genomics is the foundation of precision medicine, global food security and virus
surveillance. Exact-match is one of the most essential operations widely used in almost …

Genome analysis is a critical tool in medical and bioscience research, clinical diagnostics
and treatment, and disease control and prevention. Seed and extension-based alignment is …

Read alignment is a time-consuming step in genome sequencing analysis. The most widely
used software for read alignment, BWA-MEM, and the recently published faster version BWA …

The cost of DNA sequencing has dropped exponentially over the past decade, making
genomic data accessible to a growing number of scientists. In bioinformatics, localization of …

Next-generation sequencing (NGS) technologies have enabled affordable sequencing of
billions of short DNA fragments at high throughput, paving the way for population-scale …

FM-index is a compact data structure suitable for fast matches of short reads to large
reference genomes. The matching algorithm using this index exhibits irregular memory …