CC chemokines, a subfamily of 27 chemotactic cytokines, are a component of intercellular
communication, which is crucial for the functioning of the tumor microenvironment. Although …

Sixteen years ago, the Nomenclature Committee of the International Union of Pharmacology
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …

The CCR5 chemokine receptor acts as a co-receptor for HIV-1 viral entry. Here we report the
2.7 angstrom–resolution crystal structure of human CCR5 bound to the marketed HIV drug …

Chemokines are a family of cytokines that orchestrate the migration and positioning of
immune cells within tissues and are critical for the function of the immune system. CCR2 …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

▪ Abstract Chemokines compose a sophisticated communication system used by all our cell
types, including immune cells. Chemokine messages are decoded by specific receptors that …

Macrophage inflammatory protein-1α (MIP-1α) and MIP-1β are highly related members of
the CC chemokine subfamily. Despite their structural similarities, MIP-1α and MIP-1β show …

The surge in interest in chemokines is explained by the recognition that numerous aspects
of immunity are intimately related to leukocyte traffic. Chemokines are leukocyte attractants …

Chemokines play well established roles as attractants of naïve and effector T cells. New
studies indicate that chemokines also have roles in regulating T cell differentiation. Blocking …

Sixteen years ago, the Nomenclature Committee of the International Union of Pharmacology
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …