The induction and action of type I interferon (IFN) is of fundamental importance in human
immune defenses toward microbial pathogens, particularly viruses. Basic discoveries within …

The hyper-IgE syndromes (HIES) are a heterogeneous group of inborn errors of immunity
sharing manifestations including increased infection susceptibility, eczema, and raised …

Delayed tooth eruption (DTE) is the emergence of a tooth into the oral cavity at a time that
deviates significantly from norms established for different races, ethnicities, and sexes. This …

Autosomal dominant deficiency of signal transducer and activator of transcription 3 (STAT3)
is the main genetic etiology of hyper-immunoglobulin (Ig) E syndrome. We documented the …

OBJECTIVE: The autosomal-dominant form of the hyperimmunoglobulin E syndrome (AD-
HIES) has been described as a multisystem disorder including immune, skeletal, and dental …

The hyper‐immunoglobulin E (IgE) syndromes (HIES) are primary immunodeficiencies
characterized by the clinical triad of recurrent staphylococcal abscesses, recurrent cyst …

The hyper-IgE syndromes (HIES) are rare primary immune deficiencies characterized by
elevated serum IgE, rash, and recurrent bacterial infections of the skin and lung. Autosomal …

Autosomal dominant hyper‐IgE syndrome (AD‐HIES) or Job's syndrome is a primary
immunodeficiency with a wide array of clinical features caused by dominant negative …

The hyper-IgE syndromes (HIES; originally named Job's syndrome) are a collection of
primary immunodeficiency syndromes resulting in elevated serum IgE levels and typified by …

Abstract Autosomal dominant Hyper-IgE syndrome (AD-HIES) is a rare primary
immunodeficiency characterized by eczema, recurrent skin and lung infections, elevated …