Sites of Cre‐recombinase activity in mouse lines targeting skeletal cells

G Couasnay, MB Madel, J Lim, B Lee… - Journal of Bone and …, 2020 - academic.oup.com
ABSTRACT The Cre/Lox system is a powerful tool in the biologist's toolbox, allowing loss‐of‐
function and gain‐of‐function studies, as well as lineage tracing, through gene …

The emerging role of cell transdifferentiation in skeletal development and diseases

K Wang, C Ma, JQ Feng, Y Jing - International Journal of Molecular …, 2022 - mdpi.com
The vertebrate musculoskeletal system is known to be formed by mesenchymal stem cells
condensing into tissue elements, which then differentiate into cartilage, bone …

[HTML][HTML] MiR-6924-5p-rich exosomes derived from genetically modified Scleraxis-overexpressing PDGFRα (+) BMMSCs as novel nanotherapeutics for treating …

W Feng, Q Jin, Y Ming-Yu, H Yang, T Xu, S You-Xing… - Biomaterials, 2021 - Elsevier
Osteolysis at the tendon-bone interface can impair pullout strength during tendon-bone
healing and lead to surgery failure, but the effects of clinical treatments are not satisfactory …

[HTML][HTML] Tendon cells root into (instead of attach to) humeral bone head via fibrocartilage-enthesis

Z Wang, C Ma, D Chen, C Haslett, C Xu… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
Large joints are composed of two closely linked cartilages: articular cartilage (AC; rich in
type II collagen, a well-studied tissue) and fibrocartilaginous enthesis (FE; rich in type I …

Evolution and development of the mammalian jaw joint: Making a novel structure

N Anthwal, AS Tucker - Evolution & Development, 2023 - Wiley Online Library
A jaw joint between the squamosal and dentary is a defining feature of mammals and is
referred to as the temporomandibular joint (TMJ) in humans. Driven by changes in dentition …

Short-term effects of mechanical loading on the transdifferentiation of condylar chondrocytes

A Gross, PH Buschang, A Shakya, Y Jing - American Journal of …, 2023 - Elsevier
Introduction Transdifferentiation of chondrocytes into bone cells explains most of the
prenatal and early postnatal condylar growth, but its role during later postnatal growth and …

The effects of dietary loading on the transdifferentiation of condylar chondrocytes

A Janssen, PH Buschang, LP Tadlock… - American Journal of …, 2024 - Elsevier
Introduction Transdifferentiation of chondrocytes into bone cells explains most condylar
growth during prenatal and early postnatal stages, but the mechanisms regulating …

Divergent chondro/osteogenic transduction laws of fibrocartilage stem cell drive temporomandibular joint osteoarthritis in growing mice

R Bi, Q Li, H Li, P Wang, H Fang, X Yang… - International Journal of …, 2023 - nature.com
The anterior disc displacement (ADD) leads to temporomandibular joint osteoarthritis
(TMJOA) and mandibular growth retardation in adolescents. To investigate the potential …

大鼠颞下颌关节骨关节炎中髁突软骨与骨髓的单细胞转录组分析

余也可, 丁若仪, 孙家莉, 张志愿, 何冬梅 - 中国口腔颌面外科杂志, 2023 - cjoms.org
目的: 以单细胞分辨率解析髁突软骨及骨髓的细胞组成与功能, 及其在异常咬合应力下导致的颞
下颌关节骨关节炎(temporomandibular joint osteoarthritis, TMJOA) 中的变化. 方法 …

Single-cell transcription atlas for mandibular condyle cartilage and subchondral bone marrow in rat temporomandibular joint osteoarthritis

YU Ye-ke, D Ruo-yi, SUN Jia-li, Z Zhi-yuan… - China Journal of Oral …, 2023 - cjoms.org
PURPOSE: To establish the single-cell transcriptome atlas for rat condyle osteochondral
tissue and bone marrow both in normal and temporomandibular joint osteoarthritis (TMJOA) …