There has been a steep increase in the prevalence of dementia in recent decades, which
has roughly followed an increase in pesticide use some decades earlier, a time when it is …

Paroxonase 1 displays multiple physiological activities that position it as a putative player in
the pathogenesis of neurological disorders. Here we reviewed the literature focusing on the …

High-density lipoprotein (HDL) exhibits cardio-and neuro-protective properties, which are
thought to be promoted by paraoxonase 1 (PON1), a hydrolytic enzyme associated with an …

The human body has biological redox systems capable of preventing or mitigating the
damage caused by increased oxidative stress throughout life. One of them are the …

Paraoxonase 1 (PON1) is an enzyme which is mainly synthesized in the liver. PON1
circulates in the blood bound to HDL and delays or prevents the oxidation of LDL. Single …

Alzheimer's disease (AD) is a late-onset progressive neurodegenerative disorder which
results in the irreversible loss of cortical neurons, particularly in the associative neocortex …

Background: Human exposure to insecticides raises serious public health concerns
worldwide. Insecticides constitute a wide-ranging heterogeneous group of chemicals, most …

Previous studies have shown association of single nucleotide polymorphisms (SNPs) in 3
contiguous genes (PON1, PON2, and PON3) encoding paraoxonase with risk of Alzheimer …

Abstract Paraoxonase 1 (PON1) activity was determined using phenylacetate as substrate
(arylesterase activity) in 304 individuals with dementia–136 recognised as probable …

Aim: This study aimed to evaluate the association of the paraoxonase (PON) gene variants
and Alzheimer disease (AD) using meta-analysis. Methods: Relevant studies were identified …