Herein we trace links between biochemical pathways, pathogenesis, and metabolic
diseases to set the stage for new therapeutic advances. Cellular and acellular …

Breast cancer metastatic progression to critical secondary sites is the second leading cause
of cancer-related mortality in women. While existing therapies are highly effective in …

Cancer, a prevalent and complex disease, presents a significant challenge to the medical
community. It is characterized by irregular cell differentiation, excessive proliferation …

Background: In recent decades, obesity has widely emerged as an important risk factor for
prostate cancer (PCa). Adipose tissue and PCa cells have been shown to orchestrate a …

Breast cancer (BC) is the first worldwide most frequent cancer in both sexes and the most
commonly diagnosed in females. Although BC mortality has been thoroughly declining over …

Extracellular vesicles (EVs) are small lipid bilayer–enclosed vesicles that mediate vital
cellular communication by transferring cargo between cells. Among these, tissue-derived …

Extracellular vesicles (EVs) have lately arisen as new metabolic players in energy
homeostasis participating in intercellular communication at the local and distant levels …

Higher body fat content is related to a higher risk of mortality, and obesity-related cancer
represents approximately 40% of all cancer patients diagnosed each year. Furthermore …

Periprostatic adipose tissue (PPAT) has emerged as a key player in the prostate cancer
(PCa) microenvironment. In this study, we evaluated the ability of PPAT to promote PCa cell …

The tumor microenvironment (TME) is a complex network of cellular and non-cellular
components surrounding the tumor. The cellular component includes fibroblasts, adipocytes …