Autoimmune diseases are a diverse group of conditions characterized by aberrant B cell
and T cell reactivity to normal constituents of the host. These diseases occur widely and …

The intestinal barrier protects the host against gut microbes, food antigens, and toxins
present in the gastrointestinal tract. However, gut barrier integrity can be affected by intrinsic …

The use of probiotics by cancer patients is increasing, including among those undergoing
immune checkpoint inhibitor (ICI) treatment. Here, we elucidate a critical microbial-host …

The gut microbiota has a critical role in the maintenance of immune homeostasis. Alterations
in the intestinal microbiota and gut microbiota-derived metabolites have been recognized in …

Immune tolerance deletes or suppresses autoreactive lymphocytes and is established at
multiple levels during the development, activation and effector phases of T and B cells …

Research elucidating the pathogenesis of systemic lupus erythematosus (SLE) has defined
two critical families of mediators, type I interferon (IFN-I) and autoantibodies targeting nucleic …

Low-grade inflammation is the hallmark of metabolic disorders such as obesity, type 2
diabetes and nonalcoholic fatty liver disease. Emerging evidence indicates that these …

Impressive progress has been made over the last several years toward understanding how
almost every aspect of the immune system contributes to the expression of systemic …

Autoimmune diseases, including inflammatory bowel disease, multiple sclerosis and
rheumatoid arthritis, have distinct clinical presentations but share underlying patterns of gut …

Systemic lupus erythematosus (SLE) is a devastating autoimmune disease that can result in
substantial morbidity and mortality. Diagnosis and treatment of SLE are clinical challenges …