Therapeutic potential of plant oxylipins

T Savchenko, E Degtyaryov, Y Radzyukevich… - International Journal of …, 2022 - mdpi.com
For immobile plants, the main means of protection against adverse environmental factors is
the biosynthesis of various secondary (specialized) metabolites. The extreme diversity and …

Immunopotentiating significance of conventionally used plant adaptogens as modulators in biochemical and molecular signalling pathways in cell mediated …

P Kaur, VO Makanjuola, R Arora, B Singh… - Biomedicine & …, 2017 - Elsevier
Natural products are of great surge in the identification of chemopreventive agents and
biologically active molecules for the development of new promising therapeutic agents …

Normalization of HPA axis, cholinergic neurotransmission, and inhibiting brain oxidative and inflammatory dynamics are associated with the adaptogenic-like effect of …

JOT Emudainohwo, B Ben-Azu, OG Adebayo… - Journal of Molecular …, 2023 - Springer
Social defeat stress (SDS) due to changes in biochemical functions has been implicated in
the pathogenesis of affective and cognitive disorders. Employing pharmacological approach …

Reversal and preventive pleiotropic mechanisms involved in the antipsychotic-like effect of taurine, an essential β-amino acid in ketamine-induced experimental …

B Ben-Azu, CI Uruaka, AM Ajayi, TA Jarikre… - Neurochemical …, 2023 - Springer
Schizophrenia is a life disabling, multisystem neuropsychiatric disease mostly derived from
complex epigenetic-mediated neurobiological changes causing behavioural deficits …

Preventive putative mechanisms involved in the psychopathologies of mice passively coping with psychosocial defeat stress by quercetin

PI Ugwu, B Ben-Azu, SU Ugwu, CI Uruaka… - Brain Research …, 2022 - Elsevier
Derangements of neuroimmune, neurotrophic and neurochemical homeostasis have
important implications in psychosocial stress-induced psychopathologies. Whether …

Hydrogen sulfide protects against chronic unpredictable mild stress‐induced oxidative stress in hippocampus by upregulation of BDNF‐TrkB pathway

M Hu, W Zou, CY Wang, X Chen… - Oxidative Medicine …, 2016 - Wiley Online Library
Chronic unpredictable mild stress (CUMS) induces hippocampal oxidative stress. H2S
functions as a neuroprotectant against oxidative stress in brain. We have previously shown …

Morin hydrate attenuates chronic stress-induced memory impairment and degeneration of hippocampal subfields in mice: The role of oxidative, nitrergic and …

A Elizabeth, A Adegbuyi, A Olusegun… - Metabolic Brain …, 2020 - Springer
Morin hydrate (MH) is the major flavonoid constituent of Morus alba acclaimed to have
antioxidant, anti-inflammatory, anti-stress and neuroprotective properties. However, report …

d-Ribose–l-cysteine exhibits adaptogenic-like activity through inhibition of oxido-inflammatory responses and increased neuronal caspase-3 activity in mice exposed …

L Okoh, AM Ajayi, B Ben-Azu, ET Akinluyi… - Molecular Biology …, 2020 - Springer
Adaptogens are substances that act nonspecifically to combat stress by regulating the key
elements involved in stress-induced pathologies. d-Ribose–l-cysteine (DRLC), a potent …

Impact of ketamine administration on chronic unpredictable stress‐induced rat model of depression during extremely low‐frequency electromagnetic field exposure …

M Salari, SH Eftekhar‐Vaghefi… - Brain and …, 2023 - Wiley Online Library
Objectives In the study, we examined the effects of ketamine and extremely low‐frequency
electromagnetic fields (ELF‐EMF) on depression‐like behavior, learning and memory …

Antidepressant-like activity of methyl jasmonate involves modulation of monoaminergic pathways in mice

S Umukoro, A Adebesin, G Agu, O Omorogbe… - Advances in medical …, 2018 - Elsevier
Purpose The efficacy of current antidepressant drugs has been compromised by adverse
effects, low remission and delay onset of action necessitating the search for alternative …