Millions of people worldwide are bilaterally blind due to corneal diseases including
infectious etiologies, trauma, and chemical injuries. While corneal transplantation can …

Corneal alkali burns represent a prevalent ophthalmic emergency with the potential to
induce blindness. The main contributing mechanisms include excessive inflammation and …

Ocular trauma is a significant cause of blindness worldwide, particularly if associated with
glaucoma. Direct damage from blunt or penetrating trauma, bleeding, inflammation, lens …

Previous studies have demonstrated that ocular injury can lead to prompt infiltration of bone-
marrow–derived peripheral monocytes into the retina. However, the ability of these cells to …

Eyes that have experienced alkali burn to the surface are excessively susceptible to
subsequent severe glaucoma and retinal ganglion cell loss, despite maximal efforts to …

Purpose: This study aimed to develop a clinically feasible and practical therapy for multi-
ocular protection following ocular injury by using a thermosensitive drug delivery system …

Purpose: To review clinical aspects and cellular and molecular steps in the development of
long-term glaucoma after corneal surgery or acute trauma—especially the pivotal role of …

Reactive microglia and infiltrating peripheral monocytes have been implicated in many
neurodegenerative diseases of the retina and CNS. However, their specific contribution in …

The transcription factor forkhead box protein (FOX)-O3 is a core regulator of cellular
homeostasis, stress response, and longevity. The cellular localization of FOXO3 is closely …

Inflammation plays an important role in pathological angiogenesis. Receptor-interacting
protein 1 (RIP1) is highly expressed in inflammatory cells and is known to play an important …