Th1 concomitant immune response mediated by IFN-γ protects against sand fly delivered Leishmania infection: Implications for vaccine design

N Seyed, S Rafati - Cytokine, 2021 - Elsevier
Leishmaniasis is an unresolved global health problem with a high socio-economic impact.
Data generated in mouse models has revealed that the Th1 response, with IL-12, IFN-γ, TNF …

Anti-leishmanial therapy: Caught between drugs and immune targets

H Mahor, A Mukherjee, A Sarkar, B Saha - Experimental Parasitology, 2023 - Elsevier
Leishmaniasis is an enigmatic disease that has very restricted options for chemotherapy and
none for prophylaxis. As a result, deriving therapeutic principles for curing the disease has …

Leishmania tarentolae as Potential Live Vaccine Co-Expressing Distinct Salivary Gland Proteins Against Experimental Cutaneous Leishmaniasis in BALB/c Mice …

MS Lajevardi, E Gholami, T Taheri, H Sarvnaz… - Frontiers in …, 2022 - frontiersin.org
Leishmaniasis is a neglected vector-borne disease caused by Leishmania parasites
transmitted through the infected sand flies bite. Current treatments are limited, partly due to …

Engineering a vector-based pan-Leishmania vaccine for humans: proof of principle

P Cecílio, J Oristian, C Meneses, TD Serafim… - Scientific Reports, 2020 - nature.com
Leishmaniasis is a spectrum of diseases transmitted by sand fly vectors that deposit
Leishmania spp. parasites in the host skin during blood feeding. Currently, available …

Der p2‑A20 DNA vaccine attenuates allergic inflammation in mice with allergic rhinitis

W Hu, L Ma, G Yang, X Zeng, J Liu… - Molecular …, 2019 - spandidos-publications.com
Allergic rhinitis (AR) is a common disease that requires more convenient, safe and effective
antigen‑specific immunotherapies. The present study aimed to investigate the therapeutic …

[HTML][HTML] An overview of the sand fly salivary proteins in vaccine development against leishmaniases

S Fayaz, F Bahrami, P Parvizi… - Iranian Journal of …, 2022 - ncbi.nlm.nih.gov
Leishmaniases are a group of vector-borne parasitic diseases transmitted through the
infected sand flies. Leishmania parasites are inoculated into the host skin along with sand fly …

Structural analysis of PpSP15 and PsSP9 sand fly salivary proteins designed with a self-cleavable linker as a live vaccine candidate against cutaneous leishmaniasis

MS Lajevardi, T Taheri, E Gholami, N Seyed… - Parasites & Vectors, 2022 - Springer
Background Leishmania parasites are deposited in the host through sand fly bites along
with sand fly saliva. Therefore, salivary proteins are promising vaccine candidates for …

Ayaconin, a novel inhibitor of the plasma contact system from the sand fly Lutzomyia ayacuchensis, a vector of Andean-type cutaneous leishmaniasis

S Kawahori, C Seki, D Mizushima, A Tabbabi… - Acta Tropica, 2022 - Elsevier
Transcriptome analysis of the salivary gland cDNA library from a phlebotomine sand fly,
Lutzomyia ayacuchensis, identified a transcript coding for the PpSP15/SL1 family protein as …

[HTML][HTML] Leishmania parasite: The impact of new serum-free medium as an alternative for fetal bovine serum

S Habibzadeh, D Doroud, T Taheri… - Iranian Biomedical …, 2021 - ncbi.nlm.nih.gov
Background: Flagellated protozoan of the genus Leishmania is the causative agent of vector-
borne parasitic diseases of leishmaniasis. Since the production of recombinant …

Some good and some bad: Sand fly salivary proteins in the control of leishmaniasis and in autoimmunity

V Aoki, M Abdeladhim, N Li, P Cecilio… - Frontiers in cellular …, 2022 - frontiersin.org
Sand flies are hematophagous insects responsible for the transmission of vector-borne
diseases to humans. Prominent among these diseases is Leishmaniasis that affects the skin …