Prostate cancer review: genetics, diagnosis, treatment options, and alternative approaches
M Sekhoacha, K Riet, P Motloung, L Gumenku… - Molecules, 2022 - mdpi.com
Simple Summary Prostate cancer affects men of all racial and ethnic groups and leads to
higher rates of mortality in those belonging to a lower socioeconomic status due to late …
higher rates of mortality in those belonging to a lower socioeconomic status due to late …
PARP inhibitor resistance: the underlying mechanisms and clinical implications
Due to the DNA repair defect, BRCA1/2 deficient tumor cells are more sensitive to PARP
inhibitors (PARPi) through the mechanism of synthetic lethality. At present, several PAPRi …
inhibitors (PARPi) through the mechanism of synthetic lethality. At present, several PAPRi …
Biomarkers for homologous recombination deficiency in cancer
Defective DNA repair is a common hallmark of cancer. Homologous recombination is a DNA
repair pathway of clinical interest due to the sensitivity of homologous recombination …
repair pathway of clinical interest due to the sensitivity of homologous recombination …
Hereditary breast and ovarian cancer: new genes in confined pathways
FC Nielsen, T van Overeem Hansen… - Nature Reviews …, 2016 - nature.com
Genetic abnormalities in the DNA repair genes BRCA1 and BRCA2 predispose to hereditary
breast and ovarian cancer (HBOC). However, only approximately 25% of cases of HBOC …
breast and ovarian cancer (HBOC). However, only approximately 25% of cases of HBOC …
Germline and somatic mutations in homologous recombination genes predict platinum response and survival in ovarian, fallopian tube, and peritoneal carcinomas
KP Pennington, T Walsh, MI Harrell, MK Lee… - Clinical Cancer …, 2014 - AACR
Purpose: Hallmarks of germline BRCA1/2-associated ovarian carcinomas include
chemosensitivity and improved survival. The therapeutic impact of somatic BRCA1/2 …
chemosensitivity and improved survival. The therapeutic impact of somatic BRCA1/2 …
[HTML][HTML] Properties and behavior of carbon nanomaterials when interfacing neuronal cells: How far have we come?
In the last two decades, an increasing amount of studies have investigated the use of
components based on carbon-(nano) materials in the engineering of neural interfaces, to …
components based on carbon-(nano) materials in the engineering of neural interfaces, to …
[HTML][HTML] Re-education of tumor-associated macrophages by CXCR2 blockade drives senescence and tumor inhibition in advanced prostate cancer
D Di Mitri, M Mirenda, J Vasilevska, A Calcinotto… - Cell reports, 2019 - cell.com
Tumor-associated macrophages (TAMs) represent a major component of the tumor
microenvironment supporting tumorigenesis. TAMs re-education has been proposed as a …
microenvironment supporting tumorigenesis. TAMs re-education has been proposed as a …
[HTML][HTML] In vitro and in vivo model systems used in prostate cancer research
D Cunningham, Z You - Journal of biological methods, 2015 - ncbi.nlm.nih.gov
New incidence of prostate cancer is a major public health issue in the Western world, and
has been rising in other areas of the globe in recent years. In an effort to understanding the …
has been rising in other areas of the globe in recent years. In an effort to understanding the …
Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress
Loss of function of the phosphatase and tensin homolog deleted on chromosome 10 (PTEN)
tumor suppressor gene is associated with many human cancers. In the cytoplasm, PTEN …
tumor suppressor gene is associated with many human cancers. In the cytoplasm, PTEN …
Therapeutic applications of PARP inhibitors: anticancer therapy and beyond
The aim of this article is to describe the current and potential clinical translation of
pharmacological inhibitors of poly (ADP-ribose) polymerase (PARP) for the therapy of …
pharmacological inhibitors of poly (ADP-ribose) polymerase (PARP) for the therapy of …