Silver jubilee of stroke thrombolysis with alteplase: evolution of the therapeutic window

Y Pan, G Shi - Frontiers in Neurology, 2021 - frontiersin.org
In 1995, the results of a landmark clinical trial by National Institute of Neurological Disorders
and Stroke (NINDS) made a paradigm shift in managing acute cerebral ischemic stroke …

[HTML][HTML] Obesity, thrombosis, venous disease, lymphatic disease, and lipedema: An obesity medicine association (OMA) clinical practice statement (CPS) 2023

S Bindlish, J Ng, W Ghusn, A Fitch, HE Bays - Obesity Pillars, 2023 - Elsevier
Abstract Background This Obesity Medicine Association (OMA) Clinical Practice Statement
(CPS) is intended to provide clinicians with an overview on obesity, thrombosis, venous …

Modulation of Abundance and Location of High-Mobility Group Box 1 in Human Microglia and Macrophages under Oxygen–Glucose Deprivation

PB Bielawski, I Zhang, C Correa-Paz… - ACS Pharmacology & …, 2024 - ACS Publications
While stroke represents one of the main causes of death worldwide, available effective drug
treatment options remain limited to classic thrombolysis with recombinant tissue …

[HTML][HTML] Thrombolysis: Observations and numerical models

R Petkantchin, R Padmos, KZ Boudjeltia… - Journal of …, 2022 - Elsevier
This perspective paper considers thrombolysis in the context of ischemic strokes, intending
to build eventually a numerical model capable of simulating the thrombolytic treatment and …

The budget impact of alteplase in the treatment of acute ischemic stroke in Egypt

H Aref, N El Nahas, GH Elsisi, H Shokri… - Frontiers in …, 2023 - frontiersin.org
Introduction Stroke is the second leading cause of mortality worldwide. Five percent of all the
disability-adjusted life years (DALYs) lost around the world are attributed to stroke. This …

Tumor Embolic Stroke: The Importance of Pathological Assessment of Clots after Thrombectomy

R Baker, Z Bakali, JS Crocker, A Mowla… - Journal of Clinical …, 2024 - mdpi.com
While tumor emboli are a rare cause of stroke in cancer patients, they highlight the
importance of gross observations and pathological assessments in the evaluation of clots. In …

Drugs Resistance in Heart Diseases

A Mahmood, M Eqan, S Pervez, R Javed… - Biochemistry of Drug …, 2021 - Springer
Heart is a vital blood pumping organ of human body. Cholesterol buildup, smoking, obesity
and high blood pressure causes heart malfunctioning leading to heart diseases. Coronary …

[HTML][HTML] Management of pediatric strokes with alteplase (tissue plasminogen activator)

A Filatov, J Alvarez, J Seibert, M Swerdloff - Cureus, 2021 - ncbi.nlm.nih.gov
In the pediatric population, ischemic stroke is rare. Pediatric patients with acute ischemic
stroke are eligible for intravenous thrombolysis and/or mechanical thrombectomy. However …

Clinical pharmacokinetics and pharmacodynamics of desmoteplase

B Piechowski-Jozwiak, E Abidi, WS El Nekidy… - European Journal of …, 2022 - Springer
Desmoteplase is a bat (Desmodus rotundus) saliva-derived fibrinolytic enzyme resembling a
urokinase and tissue plasminogen activator. It is highly dependent on fibrin and has some …

Roles of Sustainable Biomaterials in Biomedical Engineering for Ischemic Stroke Therapy

FA Othman, AM Satar, SC Tan - Sustainable Material for Biomedical …, 2023 - Springer
Abstracts Ischemic stroke is the leading cause of adult disability which imposes high socio-
economic burden worldwide. Natural and synthetic biomaterials have been elucidated as …