[HTML][HTML] Oxidative stress and mitochondrial dysfunction in early-onset and late-onset preeclampsia

R Marín, DI Chiarello, C Abad, D Rojas… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Preeclampsia is a pregnancy-specific syndrome with multisystem involvement which leads
to foetal, neonatal, and maternal morbidity and mortality. This syndrome is characterized by …

Selenium and its supplementation in cardiovascular disease—what do we know?

C Benstoem, A Goetzenich, S Kraemer, S Borosch… - Nutrients, 2015 - mdpi.com
The trace element selenium is of high importance for many of the body's regulatory and
metabolic functions. Balanced selenium levels are essential, whereas dysregulation can …

Peroxiredoxin functions as a peroxidase and a regulator and sensor of local peroxides

SG Rhee, HA Woo, IS Kil, SH Bae - Journal of Biological Chemistry, 2012 - ASBMB
Peroxiredoxins (Prxs) contain an active site cysteine that is sensitive to oxidation by H 2 O 2.
Mammalian cells express six Prx isoforms that are localized to various cellular …

Chemistry of biologically important synthetic organoselenium compounds

G Mugesh, WW du Mont, H Sies - Chemical reviews, 2001 - ACS Publications
The element selenium was discovered in 1818 by the Swedish chemist Berzelius and was
named after the Greek goddess of the moon, Selene. 1 In biology, selenium was long …

Selenoprotein gene nomenclature

VN Gladyshev, ES Arnér, MJ Berry… - Journal of Biological …, 2016 - ASBMB
The human genome contains 25 genes coding for selenocysteine-containing proteins
(selenoproteins). These proteins are involved in a variety of functions, most notably redox …

From selenium to selenoproteins: synthesis, identity, and their role in human health

LV Papp, J Lu, A Holmgren… - Antioxidants & redox …, 2007 - liebertpub.com
The requirement of the trace element selenium for life and its beneficial role in human health
has been known for several decades. This is attributed to low molecular weight selenium …

Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling

SG Rhee, HZ Chae, K Kim - Free radical biology and Medicine, 2005 - Elsevier
The observation that purified yeast glutamine synthetase is rapidly inactivated in a thiol-
containing buffer yet retains activity in crude extracts containing the same thiol led to our …

The antioxidant role of selenium and seleno-compounds

H Tapiero, DM Townsend, KD Tew - Biomedicine & pharmacotherapy, 2003 - Elsevier
Selenium (Se) is an essential trace element for animals and humans that is obtained from
dietary sources including cereals, grains and vegetables. The Se content of plants varies …

Thioredoxin reductase

D Mustacich, G Powis - Biochemical Journal, 2000 - portlandpress.com
The mammalian thioredoxin reductases (TrxRs) are a family of selenium-containing pyridine
nucleotide-disulphide oxidoreductases with mechanistic and sequence identity, including a …

Selenoproteins

J Lu, A Holmgren - Journal of Biological Chemistry, 2009 - ASBMB
Selenium is an essential micronutrient for man and animals. The role of selenium has been
attributed largely to its presence in selenoproteins as the 21st amino acid, selenocysteine …