The trace element selenium is of high importance for many of the body's regulatory and metabolic functions. Balanced selenium levels are essential, whereas dysregulation can …
SG Rhee, HA Woo, IS Kil, SH Bae - Journal of Biological Chemistry, 2012 - ASBMB
Peroxiredoxins (Prxs) contain an active site cysteine that is sensitive to oxidation by H 2 O 2. Mammalian cells express six Prx isoforms that are localized to various cellular …
G Mugesh, WW du Mont, H Sies - Chemical reviews, 2001 - ACS Publications
The element selenium was discovered in 1818 by the Swedish chemist Berzelius and was named after the Greek goddess of the moon, Selene. 1 In biology, selenium was long …
The human genome contains 25 genes coding for selenocysteine-containing proteins (selenoproteins). These proteins are involved in a variety of functions, most notably redox …
The requirement of the trace element selenium for life and its beneficial role in human health has been known for several decades. This is attributed to low molecular weight selenium …
SG Rhee, HZ Chae, K Kim - Free radical biology and Medicine, 2005 - Elsevier
The observation that purified yeast glutamine synthetase is rapidly inactivated in a thiol- containing buffer yet retains activity in crude extracts containing the same thiol led to our …
Selenium (Se) is an essential trace element for animals and humans that is obtained from dietary sources including cereals, grains and vegetables. The Se content of plants varies …
D Mustacich, G Powis - Biochemical Journal, 2000 - portlandpress.com
The mammalian thioredoxin reductases (TrxRs) are a family of selenium-containing pyridine nucleotide-disulphide oxidoreductases with mechanistic and sequence identity, including a …
J Lu, A Holmgren - Journal of Biological Chemistry, 2009 - ASBMB
Selenium is an essential micronutrient for man and animals. The role of selenium has been attributed largely to its presence in selenoproteins as the 21st amino acid, selenocysteine …