Flow and particle modelling of dry powder inhalers: Methodologies, recent development and emerging applications
Dry powder inhaler (DPI) is a device used to deliver a drug in dry powder form to the lungs.
A wide range of DPI products is currently available, with the choice of DPI device largely …
A wide range of DPI products is currently available, with the choice of DPI device largely …
Combining experimental and computational techniques to understand and improve dry powder inhalers
ABSTRACT Introduction Dry Powder Inhalers (DPIs) continue to be developed to deliver an
expanding range of drugs to treat an ever-increasing range of medical conditions; with each …
expanding range of drugs to treat an ever-increasing range of medical conditions; with each …
Numerical investigation of powder dispersion mechanisms in Turbuhaler and the contact electrification effect
Powder dispersion in dry powder inhalers (DPI) is affected by factors such as device design
and flow rate, but also electrification due to particle–particle/device collisions. This work …
and flow rate, but also electrification due to particle–particle/device collisions. This work …
In-vitro and particle image velocimetry studies of dry powder inhalers
LG Dos Reis, V Chaugule, DF Fletcher… - International Journal of …, 2021 - Elsevier
Inhalation drug delivery has seen a swift rise in the use of dry powder inhalers (DPIs) to treat
chronic respiratory conditions. However, universal adoption of DPIs has been restrained due …
chronic respiratory conditions. However, universal adoption of DPIs has been restrained due …
Understanding the role of swirling flow in dry powder inhalers implications for design considerations and pulmonary delivery
Dry powder inhalers (DPIs) are widely employed to treat respiratory diseases, offering
numerous advantages such as high dose capacity and stable formulations. However, they …
numerous advantages such as high dose capacity and stable formulations. However, they …
Image-based characterization of powder flow to predict the success of pharmaceutical minitablet manufacturing
D Blanco, O Antikainen, H Räikkönen, PT Mah… - International Journal of …, 2020 - Elsevier
Powder flowability plays an important role in die filling during tablet manufacturing. The
present study introduces a novel small-scale measuring technique for powder flow. Based …
present study introduces a novel small-scale measuring technique for powder flow. Based …
The effects of grid design on the performance of 3D-printed dry powder inhalers
The grid structure is an indispensable part of most dry powder inhalers, but the effects of grid
geometry on inhaler performance are rarely reported. This study aims to systemically …
geometry on inhaler performance are rarely reported. This study aims to systemically …
[HTML][HTML] CFD-DEM investigation of the effects of aperture size for a capsule-based dry powder inhaler
Capsule based dry powder inhalers (DPIs) often require piercing of the capsule before
inhalation, and the characteristics of the apertures (punctured holes) affect air flow and the …
inhalation, and the characteristics of the apertures (punctured holes) affect air flow and the …
Investigation on the influence of design features on the performance of dry powder inhalers: Spiral channel, mouthpiece dimension, and gas inlet
As inhaler design is rarely studied but critically important in pulmonary drug delivery, this
study investigated the influence of inhaler designs, including a novel spiral channel …
study investigated the influence of inhaler designs, including a novel spiral channel …
[HTML][HTML] Effect of transient inhalation on powder evacuation and dispersion in a typical dual air inlet dry powder inhaler
An optically accessible research dry powder inhaler (DPI) was used to investigate the impact
of initial acceleration during inhalation on the powder evacuation and drug dispersion …
of initial acceleration during inhalation on the powder evacuation and drug dispersion …