Derivation of CD7-targeted chimeric antigen receptor (7CAR) T cells often requires genetic
manipulations to ablate the CD7 gene or block CD7 cell surface expression. Our novel …

A fusion gene is the physical juxtaposition of two different genes resulting in a structure
consisting of the head of one gene and the tail of the other. Gene fusion is often a primary …

T-cell acute lymphoblastic leukemia (T-ALL) is a biologically heterogeneous malignancy,
which reflects distinctive stages of T-cell differentiation arrest. We have revisited a cohort of …

T-cell acute lymphoblastic leukemia (T-ALL) accounts for approximately 15% and 25% of
childhood and adult cases of ALL, respectively, 1, 2 and is associated with a less favorable …

Abstract TAL1/SCL/TCL5 is a critical transcription factor for hematopoietic stem cell
maintenance and regulation of early hematopoiesis. However, aberrant expression of TAL1 …

Purpose: T-lymphoid/Myeloid Mixed phenotype acute leukemia (T/M-MPAL) is ambiguous
leukemia which overlaps with early T-cell precursor lymphoblastic leukemia (ETP-ALL). We …

Infant T‐cell acute lymphoblastic leukaemia (iT‐ALL) is a very rare and poorly defined entity
with a poor prognosis. We assembled a unique series of 13 infants with T‐ALL, which …

Aim Information about fusion transcripts in acute lymphoblastic leukemia (ALL) is used to
risk‐stratify patients, decide on the treatment and to detect minimal residual disease. This …

Background Molecular alterations occur frequently in T-ALL and the potential impact of
those abnormalities on outcome is still controversial. The current study aimed to test whether …

Introduction SIL‐TAL 1 rearrangement is common in T‐cell acute lymphoblastic leukemia (T‐
ALL). However, whether this fusion gene might be used as a reliable marker of minimal …