With advances in sequencing and instrument technology, bioinformatics analysis is being
applied to batches of massive cells at single-cell resolution. High-throughput single-cell …

β-catenin/CTNNB1 is an intracellular scaffold protein that interacts with adhesion molecules
(E-cadherin/CDH1, N-cadherin/CDH2, VE-cadherin/CDH5 and α-catenins), transmembrane …

The prognosis of most patients with AML is poor due to frequent disease relapse. The cause
of relapse is thought to be from the persistence of leukemia initiating cells (LIC's) following …

Hematopoietic stem cells (HSC) are responsible for the production of mature blood cells. To
ensure that the HSC pool does not get exhausted over the lifetime of an individual, most …

Long-term survival rates in childhood acute lymphoblastic leukemia (ALL) are currently
above 85% due to huge improvements in treatment. However, 15-20% of children still …

Despite intensive chemotherapy regimens, up to 60% of adults with acute myeloid
leukaemia (AML) will relapse and eventually succumb to their disease. Recent studies …

T‐cell acute lymphoblastic leukemia (T‐ALL) is an aggressive hematological disorder that
results from the clonal transformation of T‐cell precursors. Phosphatidylinositol 3‐kinase …

Epithelial-to-mesenchymal transition (EMT) is an essential molecular and cellular process
that is part of normal embryogenesis and wound healing, and also has a ubiquitous role in …

Simple Summary As one of most malignant tumors in brain, glioblastoma (GBM) is lack of
effective treatment and the prognosis of GBM patients is still very poor despite accumulated …

Adhesion molecules play essential roles in the homeostatic regulation and malignant
transformation of hematopoietic cells. The dysregulated expression of adhesion molecules …