Quinoline‐derivatives as privileged scaffolds for medicinal and pharmaceutical chemists: A comprehensive review
The quinoline scaffolds are privileged for their numerous biological activities in the
pharmaceutical field. This moiety constitutes a well‐known space in several marketed …
pharmaceutical field. This moiety constitutes a well‐known space in several marketed …
Design and Development of COX-II Inhibitors: Current Scenario and Future Perspective
Innate inflammation beyond a threshold is a significant problem involved in cardiovascular
diseases, cancer, and many other chronic conditions. Cyclooxygenase (COX) enzymes are …
diseases, cancer, and many other chronic conditions. Cyclooxygenase (COX) enzymes are …
Anticancer, antimicrobial activities of quinoline based hydrazone analogues: Synthesis, characterization and molecular docking
Based on the biologically active heterocycle quinoline, a series (18a-p) of quinoline
hydrazone analogues were prepared, starting from 6-bromo/6-chloro-2-methyl-quinolin-4-yl …
hydrazone analogues were prepared, starting from 6-bromo/6-chloro-2-methyl-quinolin-4-yl …
Deadenylase-dependent mRNA decay of GDF15 and FGF21 orchestrates food intake and energy expenditure
S Katsumura, N Siddiqui, MR Goldsmith, JH Cheah… - Cell metabolism, 2022 - cell.com
Hepatokines, secretory proteins from the liver, mediate inter-organ communication to
maintain a metabolic balance between food intake and energy expenditure. However …
maintain a metabolic balance between food intake and energy expenditure. However …
Design and synthesis of ibuprofen-quinoline conjugates as potential anti-inflammatory and analgesic drug candidates
A new set of ibuprofen-quinoline conjugates comprising quinolinyl heterocycle and
ibuprofen moieties linked by an alkyl chain were synthesized in good yields utilizing an …
ibuprofen moieties linked by an alkyl chain were synthesized in good yields utilizing an …
Novel 1, 2, 4-triazine-quinoline hybrids: The privileged scaffolds as potent multi-target inhibitors of LPS-induced inflammatory response via dual COX-2 and 15-LOX …
Based on the observed pharmacophoric structural features for the reported dual COX/15-
LOX inhibitors and inspired by the abundance of COX/LOX inhibitory activities reported for …
LOX inhibitors and inspired by the abundance of COX/LOX inhibitory activities reported for …
Visible-light-induced and copper-catalyzed oxidative cyclization of substituted o-aminophenylacetylene for the synthesis of quinoline and indole derivatives
Q Huang, M Zhao, Y Yang, YN Niu… - Organic Chemistry …, 2021 - pubs.rsc.org
Herein, we report on the development of a mild and efficient intramolecular oxidative
cyclization reaction of substituted aromatic enamines and the C (sp3)–H bond adjacent to …
cyclization reaction of substituted aromatic enamines and the C (sp3)–H bond adjacent to …
Tailored quinoline hybrids as promising COX-2/15-LOX dual inhibitors endowed with diverse safety profile: Design, synthesis, SAR, and histopathological study
Complications of the worldwide use of non-steroidal anti-inflammatory drugs (NSAIDs)
sparked scientists to design novel harmless alternatives as an urgent need. So, a unique …
sparked scientists to design novel harmless alternatives as an urgent need. So, a unique …
Synthesis, molecular docking, analgesic, anti-inflammatory, and ulcerogenic evaluation of thiophene-pyrazole candidates as COX, 5-LOX, and TNF-α inhibitors
The thiophene bearing pyrazole derivatives (7a-j) were synthesized and examined for their
in vitro cyclooxygenase, 5-lipoxygenase, and tumour inducing factor-α inhibitory activities …
in vitro cyclooxygenase, 5-lipoxygenase, and tumour inducing factor-α inhibitory activities …
Choline Chloride-Based Deep Eutectic Systems in Sequential Friedländer Reaction and Palladium-Catalyzed sp3 CH Functionalization of Methyl Ketones
C Teja, FR Nawaz Khan - ACS omega, 2019 - ACS Publications
A volatile organic solvent-free and choline chloride (ChCl)-based deep eutectic system
(DES)-mediated sp3-CH functionalization of acetophenones 1 with benzyl alcohols 2 to the …
(DES)-mediated sp3-CH functionalization of acetophenones 1 with benzyl alcohols 2 to the …