The chemokine system is a key player in the functioning of the immune system and a sought-
after target for drug candidates. The number of experimental structures of chemokines in …

Three classes of G-protein-coupled receptor (GPCR) partners–G proteins, GPCR kinases,
and arrestins–preferentially bind active GPCRs. Our analysis suggests that the structures of …

Morphine and fentanyl are among the most used opioid drugs that confer analgesia and
unwanted side effects through both G protein and arrestin signaling pathways of μ-opioid …

Activation of the chemokine receptor CXCR4 by its chemokine ligand CXCL12 regulates
diverse cellular processes. Previously reported crystal structures of CXCR4 revealed the …

Summary Hydroxycarboxylic acid receptor 2 (HCAR2), modulated by endogenous ketone
body β-hydroxybutyrate and exogenous niacin, is a promising therapeutic target for …

The complement system plays an important role in the innate immune response to invading
pathogens. The complement fragment C5a is one of its important effector components and …

The complement receptors C3aR and C5aR1, whose signaling is selectively activated by
anaphylatoxins C3a and C5a, are important regulators of both innate and adaptive immune …

Abstract Somatostatin receptor 2 (SSTR2) is highly expressed in neuroendocrine tumors
and represents as a therapeutic target. Several peptide analogs mimicking the endogenous …

The CC motif chemokine receptor 8 (CCR8) is a class A G-protein coupled receptor that has
emerged as a promising therapeutic target in cancer. Targeting CCR8 with an antibody has …

Numerous processes contribute to the regulation of G protein–coupled receptors (GPCRs),
but relatively little is known about rapid mechanisms that control signaling on the seconds …