The beta-3 adrenergic receptor (β3-AR) is by far the least studied isotype of the beta-
adrenergic sub-family. Despite its study being long hampered by the lack of suitable animal …

Malignant melanoma is a tumor characterized by a very high level of heterogeneity,
responsible for its malignant behavior and ability to escape from standard therapies. In this …

Introduction Embryo and fetus grow and mature over the first trimester of pregnancy in a
dynamic hypoxic environment, where placenta development assures an increased oxygen …

Dry eye disease (DED) is a common ocular disorder characterized by an inadequate
lubrication of the eye by tears leading to inflammation and the alteration of the ocular …

Compelling evidence supports the hypothesis that stress negatively impacts cancer
development and prognosis. Irrespective of its physical, biological or psychological source …

A major player in the homeostatic response to hypoxia is the hypoxia-inducible factor (HIF)-1
that transactivates a number of genes involved in neovessel proliferation in response to low …

Nerves and immunologic mediators play pivotal roles in body homeostasis by interacting
with each other through diverse mechanisms. The spread of nerves in the tumor …

The role of the β‐adrenoceptors (β‐ARs) in hypoxia‐driven diseases has gained visibility
after the demonstration that propranolol promotes the regression of infantile hemangiomas …

High vascularization and locally secreted factors make the bone marrow (BM)
microenvironment particularly hospitable for tumor cells and bones to a preferred metastatic …

Simple Summary Advanced malignant melanoma still has a poor prognosis. Mortality is
closely associated with tumor recurrence, which, as with other types of cancer, can occur …