Cardiovascular and metabolic diseases (CVMD) are the leading causes of death worldwide,
underscoring the urgent necessity to develop new pharmacotherapies. Berberine (BBR) is …

Berberine is an isoquinoline alkaloid present in several plants, including Coptis sp. and
Berberis sp. Berberine is a customary component in Chinese medicine, and is characterized …

Background: Metabolic activity is the basic life activity of organisms and the fundamental for
maintaining body functions. With the improvement of living standards, the incidence of …

The complex and multifactorial nature of atherogenesis and development of
atherothrombotic complications involves numerous interactions between various cell types …

Introduction: Type 2 diabetes mellitus and hypercholesterolemia have proven to give an
increased incidence of cardiovascular diseases (CVD). Recent studies have suggested that …

Atherosclerosis (AT) is a progressive chronic disease involving lipid accumulation, fibrosis,
and inflammation in medium and large-sized arteries, and it is the main cause of …

Atherosclerosis is an epidemic across the globe [A1], and its morbidity and mortality remain
high, involving various complications and poor prognoses. In atherosclerosis, endothelial …

OBJECTIVES: Microparticles (MP) are small membrane vesicles, released from activated,
damaged and apoptotic endothelial cells (EMP) or platelets (PMP) that may actively …

Abstract Background Circulating endothelial microparticles (EMPs) lead to endothelial
dysfunction by increasing oxidative stress. Berberine has a beneficial effect on endothelial …

Berberine (BBR) is a natural alkaloid isolated from the Coptis Chinensis. While this plant has
been used in Ayurvedic and Chinese medicine for more than 2500 years, interest in its …