Bone regeneration represents a complex process, of which basic biologic principles have
been evolutionarily conserved over a broad range of different species. Bone represents one …

Abstract Purpose of Review The periosteum, the outer layer of bone, is a major source of
skeletal stem/progenitor cells (SSPCs) for bone repair. Here, we discuss recent findings on …

Esophageal squamous-cell carcinoma (ESCC), one of the most prevalent and lethal
malignant disease, has a complex but unknown tumor ecosystem. Here, we investigate the …

The periosteum is the major source of cells involved in fracture healing. We sought to
characterize progenitor cells and their contribution to bone fracture healing. The periosteum …

The outer coverings of the skeleton, which is also known as the periosteum, are arranged in
concentric layers and act as a reservoir for tissue-specific bone progenitors. The cellular …

Bone regeneration depends on a pool of bone/cartilage stem/progenitor cells and signaling
mechanisms regulating their differentiation. Using in vitro approach, we have shown that …

Musculoskeletal injuries and bone defects represent a significant clinical challenge,
necessitating innovative approaches for effective bone tissue regeneration. In this study, we …

Calcitonin gene‐related peptide (CGRP) is a neuropeptide produced by sensory nerves and
functions as a pain sensor. It acts by binding to the calcitonin‐like receptor (CLR, protein; …

Bone marrow-derived mesenchymal stem cells (BM-MSCs) play a crucial role in stem cell
therapy and are extensively used in regenerative medicine research. However, current …

In response to bone fracture, periosteal progenitor cells proliferate, expand, and differentiate
to form cartilage and bone in the fracture callus. These cellular functions require the …