Informed consent is the result of tumultuous events in both the clinical and research arenas
over the last 100 years. Throughout this time, the notion of informed consent has shifted …

Despite recent biomedical breakthroughs and large genomic studies growing momentum,
the Middle Eastern population, home to over 400 million people, is underrepresented in the …

A genetic etiology for autism spectrum disorders (ASDs) was first suggested from twin
studies reported in the 1970s. The identification of gene mutations in syndromic ASDs …

Reaching the full potential of precision medicine depends on the quality of personalized
genome interpretation. In order to facilitate precision medicine in regions of the Middle East …

Arab populations are largely understudied, notably their genetic structure and history. Here
we present an in-depth analysis of 6,218 whole genomes from Qatar, revealing extensive …

An open question in the history of human migration is the identity of the earliest Eurasian
populations that have left contemporary descendants. The Arabian Peninsula was the initial …

The severity of the new COVID-19 pandemic caused by the SARS-CoV-2 virus is strikingly
variable in different global populations. SARS-CoV-2 uses ACE2 as a cell receptor …

Background Allele frequency data from large exome and genome aggregation projects such
as the Genome Aggregation Database (gnomAD) are of ultimate importance to the …

Background Neonatal diabetes mellitus (NDM) is a rare condition that occurs within the first
six months of life. Permanent NDM (PNDM) is caused by mutations in specific genes that are …

Background This study reports on the use of whole exome sequencing (WES) to diagnose
children with inborn errors of metabolism and other disorders in United Arab Emirates …