Engineering functional polymer capsules toward smart nanoreactors

J Gaitzsch, X Huang, B Voit - Chemical reviews, 2016 - ACS Publications
The design and construction of integrated chemical ensembles for studying complex
biological systems is attracting considerable interest in a wide range of research …

All wrapped up: stabilization of enzymes within single enzyme nanoparticles

R Chapman, MH Stenzel - Journal of the American Chemical …, 2019 - ACS Publications
Enzymes are extremely useful in many industrial and pharmaceutical areas due to their
ability to catalyze reactions with high selectivity. In order to extend their lifetime, significant …

Therapeutic vesicular nanoreactors with tumor‐specific activation and self‐destruction for synergistic tumor ablation

J Li, A Dirisala, Z Ge, Y Wang, W Yin, W Ke… - Angewandte …, 2017 - Wiley Online Library
Polymeric nanoreactors (NRs) have distinct advantages to improve chemical reaction
efficiency, but the in vivo applications are limited by lack of tissue‐specificity. Herein, novel …

Permeable protein-loaded polymersome cascade nanoreactors by polymerization-induced self-assembly

LD Blackman, S Varlas, MC Arno, A Fayter… - ACS macro …, 2017 - ACS Publications
Enzyme loading of polymersomes requires permeability to enable them to interact with the
external environment, typically requiring addition of complex functionality to enable porosity …

Reversibly switching bilayer permeability and release modules of photochromic polymersomes stabilized by cooperative noncovalent interactions

X Wang, J Hu, G Liu, J Tian, H Wang… - Journal of the …, 2015 - ACS Publications
We report on the fabrication of photochromic polymersomes exhibiting photoswitchable and
reversible bilayer permeability from newly designed poly (ethylene oxide)-b-PSPA (PEO-b …

Recent advances in permeable polymersomes: fabrication, responsiveness, and applications

Y Zhu, S Cao, M Huo, JCM van Hest, H Che - Chemical science, 2023 - pubs.rsc.org
Polymersomes are vesicular nanostructures enclosed by a bilayer-membrane self-
assembled from amphiphilic block copolymers, which exhibit higher stability compared with …

Confinement of therapeutic enzymes in selectively permeable polymer vesicles by polymerization-induced self-assembly (PISA) reduces antibody binding and …

LD Blackman, S Varlas, MC Arno, ZH Houston… - ACS central …, 2018 - ACS Publications
Covalent PEGylation of biologics has been widely employed to reduce immunogenicity,
while improving stability and half-life in vivo. This approach requires covalent protein …

Compartmentalization approaches in soft matter science: from nanoreactor development to organelle mimics

L Schoonen, JCM Van Hest - Advanced Materials, 2016 - Wiley Online Library
Compartmentalization is an essential feature found in living cells to ensure that biological
processes occur without being affected by undesired external influences. Over the years …

Overcoming the incompatibility challenge in chemoenzymatic and multi‐catalytic cascade reactions

S Schmidt, K Castiglione… - Chemistry–A European …, 2018 - Wiley Online Library
Multi‐catalytic cascade reactions bear a great potential to minimize downstream and
purification steps, leading to a drastic reduction of the produced waste. In many examples …

Feedback-induced temporal control of “breathing” polymersomes to create self-adaptive nanoreactors

H Che, S Cao, JCM Van Hest - Journal of the American Chemical …, 2018 - ACS Publications
Here we present the development of self-regulated “breathing” polymersome nanoreactors
that show temporally programmable biocatalysis induced by a chemical fuel. pH-sensitive …