Molecular strategies for the utilisation of human milk oligosaccharides by infant gut-associated bacteria

LJ Kiely, K Busca, JA Lane… - FEMS Microbiology …, 2023 - academic.oup.com
A number of bacterial species are found in high abundance in the faeces of healthy breast-
fed infants, an occurrence that is understood to be, at least in part, due to the ability of these …

[HTML][HTML] The human gut microbiota during the initial stages of life: insights from bifidobacteria

F Turroni, C Milani, M Ventura… - Current Opinion in …, 2022 - Elsevier
Highlights•Establishment of host–microbe interactions has facilitated co-evolution between
the host and its resident intestinal microbiota.•These mutualistic relationships are particularly …

Infant microbiome cultivation and metagenomic analysis reveal Bifidobacterium 2'-fucosyllactose utilization can be facilitated by coexisting species

YC Lou, BE Rubin, MC Schoelmerich… - Nature …, 2023 - nature.com
The early-life gut microbiome development has long-term health impacts and can be
influenced by factors such as infant diet. Human milk oligosaccharides (HMOs), an essential …

Utilization Efficiency of Human Milk Oligosaccharides by Human-Associated Akkermansia Is Strain Dependent

E Luna, SG Parkar, N Kirmiz, S Hartel… - Applied and …, 2022 - Am Soc Microbiol
Akkermansia muciniphila is a mucin-degrading bacterium found in the human gut and is
often associated with positive human health. However, despite being detected by as early as …

Paternal and induced gut microbiota seeding complement mother-to-infant transmission

L Dubois, M Valles-Colomer, A Ponsero, O Helve… - Cell Host & Microbe, 2024 - cell.com
Microbial colonization of the neonatal gut involves maternal seeding, which is partially
disrupted in cesarean-born infants and after intrapartum antibiotic prophylaxis. However …

Birthmode and environment-dependent microbiota transmission dynamics are complemented by breastfeeding during the first year

M Selma-Royo, L Dubois, S Manara, F Armanini… - Cell host & …, 2024 - cell.com
The composition and maturation of the early-life microbiota are modulated by a number of
perinatal factors, whose interplay in relation to microbial vertical transmission remains …

Linking human milk oligosaccharide metabolism and early life gut microbiota: Bifidobacteria and beyond

C Lordan, AK Roche, D Delsing, A Nauta… - Microbiology and …, 2024 - Am Soc Microbiol
Human milk oligosaccharides (HMOs) are complex, multi-functional glycans present in
human breast milk. They represent an intricate mix of heterogeneous structures which reach …

CRISPR-Cas-based identification of a sialylated human milk oligosaccharides utilization cluster in the infant gut commensal Bacteroides dorei

S Kijner, D Ennis, S Shmorak, A Florentin… - Nature …, 2024 - nature.com
The infant gut microbiome is impacted by early-life feeding, as human milk oligosaccharides
(HMOs) found in breastmilk cannot be digested by infants and serve as nutrients for their gut …

The Infant Gut Commensal Bacteroides dorei Presents a Generalized Transcriptional Response to Various Human Milk Oligosaccharides

S Kijner, A Cher, M Yassour - Frontiers in Cellular and Infection …, 2022 - frontiersin.org
Human milk oligosaccharides (HMOs) are a family of glycans found in breastmilk with over
200 identified structures. Despite being t​​ he third-largest solid component in breastmilk …

Current advances in structure–function relationships and dose-dependent effects of human milk oligosaccharides

J Wang, MS Chen, RS Wang, JQ Hu, S Liu… - Journal of Agricultural …, 2022 - ACS Publications
HMOs (human milk oligosaccharides) are the third most important nutrient in breast milk. As
complex glycans, HMOs play an important role in regulating neonatal intestinal immunity …