Antibody responses to envelope glycoproteins in HIV-1 infection
DR Burton, JR Mascola - Nature immunology, 2015 - nature.com
Antibody responses to the HIV-1 envelope glycoproteins can be classified into three groups.
Binding but non-neutralizing responses are directed to epitopes that are expressed on …
Binding but non-neutralizing responses are directed to epitopes that are expressed on …
[HTML][HTML] Human antibodies that neutralize HIV-1: identification, structures, and B cell ontogenies
PD Kwong, JR Mascola - Immunity, 2012 - cell.com
Antibodies that neutralize diverse strains of HIV-1 develop in∼ 20% of HIV-1-infected
individuals, and isolation and structural characterization of these antibodies are revealing …
individuals, and isolation and structural characterization of these antibodies are revealing …
T cell-inducing vaccine durably prevents mucosal SHIV infection even with lower neutralizing antibody titers
Recent efforts toward an HIV vaccine focus on inducing broadly neutralizing antibodies, but
eliciting both neutralizing antibodies (nAbs) and cellular responses may be superior. Here …
eliciting both neutralizing antibodies (nAbs) and cellular responses may be superior. Here …
Holes in the glycan shield of the native HIV envelope are a target of trimer-elicited neutralizing antibodies
LE McCoy, MJ van Gils, G Ozorowski, T Messmer… - Cell reports, 2016 - cell.com
A major advance in the search for an HIV vaccine has been the development of a near-
native Envelope trimer (BG505 SOSIP. 664) that can induce robust autologous Tier 2 …
native Envelope trimer (BG505 SOSIP. 664) that can induce robust autologous Tier 2 …
The Neutralization Breadth of HIV-1 Develops Incrementally over Four Years and Is Associated with CD4+ T Cell Decline and High Viral Load during Acute Infection
An understanding of how broadly neutralizing activity develops in HIV-1-infected individuals
is needed to guide vaccine design and immunization strategies. Here we used a large panel …
is needed to guide vaccine design and immunization strategies. Here we used a large panel …
The role of antibodies in HIV vaccines
JR Mascola, DC Montefiori - Annual review of immunology, 2009 - annualreviews.org
Licensed vaccines against viral diseases generate antibodies that neutralize the infecting
virus and protect against infection or disease. Similarly, an effective vaccine against HIV-1 …
virus and protect against infection or disease. Similarly, an effective vaccine against HIV-1 …
The antibody response against HIV-1
J Overbaugh, L Morris - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Neutralizing antibodies (NAbs) typically play a key role in controlling viral infections and
contribute to the protective effect of many successful vaccines. In the case of HIV-1 infection …
contribute to the protective effect of many successful vaccines. In the case of HIV-1 infection …
VH1-69 antiviral broadly neutralizing antibodies: genetics, structures, and relevance to rational vaccine design
Broadly neutralizing antibodies (bnAbs) are potential therapeutic molecules and valuable
tools for studying conserved viral targets for vaccine and drug design. Interestingly, antibody …
tools for studying conserved viral targets for vaccine and drug design. Interestingly, antibody …
Early low-titer neutralizing antibodies impede HIV-1 replication and select for virus escape
Single genome sequencing of early HIV-1 genomes provides a sensitive, dynamic
assessment of virus evolution and insight into the earliest anti-viral immune responses in …
assessment of virus evolution and insight into the earliest anti-viral immune responses in …
Implications of HIV diversity for the HIV-1 pandemic
J Hemelaar - Journal of Infection, 2013 - Elsevier
HIV-1 genetic variability within individuals and populations plays a central role in the HIV
pandemic. Multiple zoonotic transmissions of SIV to humans have resulted in distinct HIV …
pandemic. Multiple zoonotic transmissions of SIV to humans have resulted in distinct HIV …