Calcineurin inhibitor nephrotoxicity
The use of the calcineurin inhibitors cyclosporine and tacrolimus led to major advances in
the field of transplantation, with excellent short-term outcome. However, the chronic …
the field of transplantation, with excellent short-term outcome. However, the chronic …
Tacrolimus: 20 years of use in adult kidney transplantation. What we should know about its nephrotoxicity
Y Bentata - Artificial organs, 2020 - Wiley Online Library
Abstract Tacrolimus (or FK506), a calcineurin inhibitor (CNI) introduced in field of
transplantation in the 1990s, is the cornerstone of most immunosuppressive regimens in …
transplantation in the 1990s, is the cornerstone of most immunosuppressive regimens in …
[HTML][HTML] In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation
PA Gameiro, J Yang, AM Metelo, R Pérez-Carro… - Cell metabolism, 2013 - cell.com
Hypoxic and VHL-deficient cells use glutamine to generate citrate and lipids through
reductive carboxylation (RC) of α-ketoglutarate. To gain insights into the role of HIF and the …
reductive carboxylation (RC) of α-ketoglutarate. To gain insights into the role of HIF and the …
Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates
Understanding the physical characteristics of the local microenvironment in which
Mycobacterium tuberculosis resides is an important goal that may allow the targeting of …
Mycobacterium tuberculosis resides is an important goal that may allow the targeting of …
Role of the microvascular endothelium in progressive renal disease
The role of the vascular endothelium in progressive renal disease is not well understood.
This review presents evidence that progressive renal disease is characterized by a …
This review presents evidence that progressive renal disease is characterized by a …
Haemodynamic influences on kidney oxygenation: clinical implications of integrative physiology
Renal blood flow, local tissue perfusion and blood oxygen content are the major
determinants of oxygen delivery to kidney tissue. Arterial pressure and segmental vascular …
determinants of oxygen delivery to kidney tissue. Arterial pressure and segmental vascular …
Subtle acquired renal injury as a mechanism of salt-sensitive hypertension
RJ Johnson, J Herrera-Acosta… - … England Journal of …, 2002 - Mass Medical Soc
Salt sensitivity is present in about half of people with essential hypertension; decreasing salt
intake ameliorates the hypertension. This review provides an explanation of how initially …
intake ameliorates the hypertension. This review provides an explanation of how initially …
Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production
M Safran, WY Kim, F O'Connell… - Proceedings of the …, 2006 - National Acad Sciences
Many human diseases are characterized by the development of tissue hypoxia. Inadequate
oxygenation can cause cellular dysfunction and death. Tissues use many strategies …
oxygenation can cause cellular dysfunction and death. Tissues use many strategies …
Reactive oxygen species cause diabetes-induced decrease in renal oxygen tension
Aims/hypothesis Augmented formation of reactive oxygen species (ROS) induced by
hyperglycaemia has been suggested to contribute to the development of diabetic …
hyperglycaemia has been suggested to contribute to the development of diabetic …
[PDF][PDF] Pathophysiological mechanisms of calcineurin inhibitor-induced nephrotoxicity and arterial hypertension
L Hošková, I Málek, L Kopkan… - Physiological …, 2017 - pdfs.semanticscholar.org
Solid organ transplantation is an established treatment modality in patients with end-stage
organ damage in cases where other therapeutic options fail. The long-term outcomes of …
organ damage in cases where other therapeutic options fail. The long-term outcomes of …