Heat shock proteins (hsps) are among the most abundant intracellular proteins. Their
synthesis is rapidly up-regulated by various 'stressors' including temperature, glucose …

The existence of heat‐shock protein (HSP) receptors on antigen‐presenting cells (APCs)
was hypothesized in 1994. The first such receptor, CD91 or LRP, was identified and …

Schistosomiasis remains a serious public health problem with an estimated 200 million
people infected in 76 countries. Here we isolated~ 8,400 potential protein-encoding cDNA …

Heat shock proteins (HSPs) such as gp96 are released from cells as a result of necrotic cell
death. The ability of endogenous HSP–peptide complexes to elicit antigen-specific T cells …

Heat shock protein gp96 is an endoplasmic reticulum chaperone, belonging to the HSP90
family. The function of gp96 as a molecular chaperone was discovered more than 10 years …

As an endoplasmic reticulum heat shock protein (HSP) 90 paralogue, glycoprotein (gp) 96
possesses immunological properties by chaperoning antigenic peptides for activation of T …

Schistosomiasis, caused mainly by Schistosoma japonicum, S. mansoni, and S.
hematobium, remains one of the most prevalent and serious parasitic diseases worldwide …

Heat shock proteins have been implicated as endogenous activators for dendritic cells
(DCs). Without tissue distress or death, these intracellular molecules are inaccessible to …

CTL are endowed with the ability to eliminate pathogens through perforin-mediated cytotoxic
activity. The mechanism for perforin-mediated Ag-specific killing has been solely attributed …

Over the past decade, our laboratory has developed a secreted heat shock protein (HSP),
chaperone gp96, cell-based vaccine that generates effective anti-tumor and anti-infectious …