A chemical perspective on the modulation of TEAD transcriptional activities: Recent progress, challenges, and opportunities

J Lou, Y Lu, J Cheng, F Zhou, Z Yan, D Zhang… - European Journal of …, 2022 - Elsevier
TEADs are transcription factors and core downstream components of the Hippo pathway.
Mutations of the Hippo pathway and/or dysregulation of YAP/TAZ culminate in aberrant …

Recent advances of β-catenin small molecule inhibitors for cancer therapy: Current development and future perspectives

P Yang, Y Zhu, Q Zheng, S Meng, Y Wu… - European journal of …, 2022 - Elsevier
The Wnt/β-catenin signaling pathway is involved in many cellular physiological processes,
including embryonic development, cell proliferation and differentiation, tissue homeostasis …

Medicinal chemistry strategies for the development of inhibitors disrupting β-catenin's interactions with its nuclear partners

H Zhang, C Liu, D Zhu, Q Zhang… - Journal of Medicinal …, 2022 - ACS Publications
Dysregulation of the Wnt/β-catenin signaling pathway is strongly associated with various
aspects of cancer, including tumor initiation, proliferation, and metastasis as well as …

Blocking the WNT/β-catenin pathway in cancer treatment: pharmacological targets and drug therapeutic potential

X Zhao, Y Ma, J Luo, K Xu, P Tian, C Lu, J Song - Heliyon, 2024 - cell.com
The WNT/β-catenin signaling pathway plays crucial roles in tumorigenesis and relapse,
metastasis, drug resistance, and tumor stemness maintenance. In most tumors, the WNT/β …

Discovery of Novel 1-Phenylpiperidine Urea-Containing Derivatives Inhibiting β-Catenin/BCL9 Interaction and Exerting Antitumor Efficacy through the Activation of …

W Zhu, C Liu, K Xi, A Li, L Shen, Y Li… - Journal of Medicinal …, 2024 - ACS Publications
Aberrant activation of the Wnt/β-catenin signaling is associated with tumor development, and
blocking β-catenin/BCL9 is a novel strategy for oncogenic Wnt/β-catenin signaling. Herein …

Helical sulfono-γ-AApeptides with predictable functions in protein recognition

P Sang, Y Shi, L Wei, J Cai - RSC Chemical Biology, 2022 - pubs.rsc.org
Sulfono-γ-AApeptides are a subset of possible sequence-specific foldamers that might be
considered for the design of biomimetic drug molecular structures. Although they have been …

Discovery of an Orally Bioavailable Small-Molecule Inhibitor for the β-Catenin/B-Cell Lymphoma 9 Protein–Protein Interaction

Z Wang, M Zhang, V Quereda… - Journal of medicinal …, 2021 - ACS Publications
Aberrant activation of Wnt/β-catenin signaling is strongly associated with many diseases
including cancer invasion and metastasis. Small-molecule targeting of the central signaling …

New ZW4864 Derivatives as Small-Molecule Inhibitors for the β-Catenin/BCL9 Protein–Protein Interaction

Z Wang, M Zhang, HM Thompson… - ACS Medicinal Chemistry …, 2022 - ACS Publications
A series of 1-(3-(2-amino-2-oxoethoxy) phenyl) piperidine-3-carboxamide derivatives was
reported as new small-molecule β-catenin/B-cell lymphoma 9 (BCL9) protein–protein …

Discovery of Small-Molecule Inhibitors for the β-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction

Z Li - 2023 - search.proquest.com
The Wnt/β‐catenin signaling pathway is associated with activating genes that support cell
proliferation, differentiation, and survival. Excessive activation of Wnt/β‐catenin signaling …

Protein-protein interactions between RUNX3 and ZEB1 in chronic lung injury induced by methamphetamine abuse

N Bao, L Cheng, Y Wang, Z Peng, Z Wang… - Frontiers in …, 2022 - frontiersin.org
Methamphetamine (MA) is the most common and highly addictive substance abuse drug.
Runt-related transcription factor 3 (RUNX3) and Zinc finger E-box-binding homeobox 1 …