The immune system plays a key role in health maintenance and pathogenesis of a wide
range of diseases. Leukocytes that are present in the blood convey valuable information …

Pathogens manipulate the cellular mechanisms of host organisms via pathogen–host
interactions (PHIs) in order to take advantage of the capabilities of host cells, leading to …

The mammalian immune system is a dynamic multiscale system composed of a
hierarchically organized set of molecular, cellular, and organismal networks that act in …

Type I and type III interferons (IFNs) are crucial components of the first-line antiviral host
response. While specific receptors for both IFN types exist, intracellular signaling shares the …

This is an exciting time for immunology because the future promises to be replete with
exciting new discoveries that can be translated to improve health and treat disease in novel …

The fidelity of T cell immunity depends greatly on coupling T cell receptor signaling with
specific T cell effector functions. Here, we describe a chromatin-based mechanism that …

Systems-level analysis of biological processes strives to comprehensively and quantitatively
evaluate the interactions between the relevant molecular components over time, thereby …

Highlights•Vaccines have eradicated smallpox, nearly eradicated polio, and resulted in
99.9% reduction in incidence rates for many diseases.•There are significant challenges …

Control of diverse pathogens requires an adaptive antibody response, dependent on
cellular division of labor to allocate antigen-dependent B-and CD4+ T-cell fates that …

Rare ovarian cancers are ovarian cancers with an annual incidence of less than 6 cases per
100,000 women. They generally have a poor prognosis due to being delayed diagnosis and …