P2X7 interactions and signaling–making head or tail of it
R Kopp, A Krautloher, A Ramírez-Fernández… - Frontiers in Molecular …, 2019 - frontiersin.org
Extracellular adenine nucleotides play important roles in cell–cell communication and tissue
homeostasis. High concentrations of extracellular ATP released by dying cells are sensed …
homeostasis. High concentrations of extracellular ATP released by dying cells are sensed …
Pharmacology and structure of P2Y receptors
I von Kügelgen, K Hoffmann - Neuropharmacology, 2016 - Elsevier
Abstract P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular
nucleotides. There are eight mammalian P2Y receptor subtypes (P2Y 1, P2Y 2, P2Y 4, P2Y …
nucleotides. There are eight mammalian P2Y receptor subtypes (P2Y 1, P2Y 2, P2Y 4, P2Y …
P2X7 receptors: channels, pores and more
C Volonte, S Apolloni, S D. Skaper… - CNS & Neurological …, 2012 - benthamdirect.com
Purine nucleotides are well established as extracellular signaling molecules. P2X7
receptors (P2X7Rs) are members of the family of ionotropic ATP-gated receptors. Their …
receptors (P2X7Rs) are members of the family of ionotropic ATP-gated receptors. Their …
Molecular pharmacology of P2Y receptor subtypes
I von Kuegelgen - Biochemical Pharmacology, 2021 - Elsevier
Abstract Professor Geoffrey Burnstock proposed the concept of purinergic signaling via P1
and P2 receptors. P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular …
and P2 receptors. P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular …
Pharmacology of P2Y receptors
I von Kügelgen - Brain research bulletin, 2019 - Elsevier
Abstract P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular
nucleotides. There are eight mammalian P2Y receptor subtypes divided into two subgroups …
nucleotides. There are eight mammalian P2Y receptor subtypes divided into two subgroups …
Pharmacological characterization of P2Y receptor subtypes–an update
I von Kügelgen - Purinergic Signalling, 2024 - Springer
Abstract P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular
nucleotides. There are eight mammalian P2Y receptor subtypes (P2Y1, P2Y2, P2Y4, P2Y6 …
nucleotides. There are eight mammalian P2Y receptor subtypes (P2Y1, P2Y2, P2Y4, P2Y6 …
The P2X7 receptor antagonist Brilliant Blue G attenuates contralateral rotations in a rat model of Parkinsonism through a combined control of synaptotoxicity …
MRS Carmo, APF Menezes, ACL Nunes, A Pliássova… - …, 2014 - Elsevier
Parkinson's disease (PD) involves an initial loss of striatal dopaminergic terminals evolving
into a degeneration of dopaminergic neurons in the substantia nigra (SN), which can be …
into a degeneration of dopaminergic neurons in the substantia nigra (SN), which can be …
P2Y13 receptors regulate microglial morphology, surveillance, and resting levels of interleukin 1β release
V Kyrargyri, C Madry, A Rifat, IL Arancibia‐Carcamo… - Glia, 2020 - Wiley Online Library
Microglia sense their environment using an array of membrane receptors. While P2Y12
receptors are known to play a key role in targeting directed motility of microglial processes to …
receptors are known to play a key role in targeting directed motility of microglial processes to …
Dual-specificity phosphatase regulation in neurons and glial cells
R Pérez-Sen, MJ Queipo, JC Gil-Redondo… - International Journal of …, 2019 - mdpi.com
Dual-specificity protein phosphatases comprise a protein phosphatase subfamily with
selectivity towards mitogen-activated protein (MAP) kinases, also named MKPs, or mitogen …
selectivity towards mitogen-activated protein (MAP) kinases, also named MKPs, or mitogen …
Inhibition of phosphodiesterase 2 reverses impaired cognition and neuronal remodeling caused by chronic stress
Chronic stress and neuronal vulnerability have recently been recognized as factors
contributing to cognitive disorders. One way to modify neuronal vulnerability is through …
contributing to cognitive disorders. One way to modify neuronal vulnerability is through …