Mechanisms of action and therapeutic efficacies of the lipophilic antimycobacterial agents clofazimine and bedaquiline
Abstract Drug-resistant (DR)-TB is the major challenge confronting the global TB control
programme, necessitating treatment with second-line anti-TB drugs, often with limited …
programme, necessitating treatment with second-line anti-TB drugs, often with limited …
The mur enzymes chink in the armour of Mycobacterium tuberculosis cell wall
Tuberculosis (TB) transmitted by Mycobacterium tuberculosis (Mtb) is one of the top 10
causes of death globally. Currently, the widespread occurrence of resistance toward Mtb …
causes of death globally. Currently, the widespread occurrence of resistance toward Mtb …
[HTML][HTML] Prevalence of Mycobacterium tuberculosis resistant to bedaquiline and delamanid in China
W He, C Liu, D Liu, A Ma, Y Song, P He, J Bao… - Journal of global …, 2021 - Elsevier
Objectives The new antituberculous drugs delamanid and bedaquiline form the last line of
defence against drug-resistant tuberculosis (TB). Understanding the background prevalence …
defence against drug-resistant tuberculosis (TB). Understanding the background prevalence …
Structural Simplification of Bedaquiline: the Discovery of 3‐(4‐(N,N‐Dimethylaminomethyl)phenyl)quinoline‐Derived Antitubercular Lead Compounds
C He, L Preiss, B Wang, L Fu, H Wen, X Zhang… - …, 2017 - Wiley Online Library
Bedaquiline (BDQ) is a novel and highly potent last‐line antituberculosis drug that was
approved by the US FDA in 2013. Owing to its stereo‐structural complexity, chemical …
approved by the US FDA in 2013. Owing to its stereo‐structural complexity, chemical …
Routes of Synthesis of Carbapenems for Optimizing Both the Inactivation of l,d-Transpeptidase LdtMt1 of Mycobacterium tuberculosis and the Stability toward …
L Iannazzo, D Soroka, S Triboulet… - Journal of Medicinal …, 2016 - ACS Publications
Combinations of β-lactams of the carbapenem class, such as meropenem, with clavulanate,
a β-lactamase inhibitor, are being evaluated for the treatment of drug-resistant tuberculosis …
a β-lactamase inhibitor, are being evaluated for the treatment of drug-resistant tuberculosis …
Bedaquiline, Delamanid, Linezolid, Clofazimine, and Capreomycin MIC Distributions for Drug Resistance Mycobacterium tuberculosis in Shanghai, China
Y Guo, J Yang, W Wang, X Wu, B Wan… - Infection and Drug …, 2023 - Taylor & Francis
Background New antituberculosis drugs have recently been approved for the treatment of
multidrug-resistant tuberculosis TB (MDR-TB). We aimed to describe the distributions of …
multidrug-resistant tuberculosis TB (MDR-TB). We aimed to describe the distributions of …
[HTML][HTML] Identification of novel benzoxa-[2, 1, 3]-diazole substituted amino acid hydrazides as potential anti-tubercular agents
Discovery and development of new therapeutic options for the treatment of Mycobacterium
tuberculosis (Mtb) infection are desperately needed to tackle the continuing global burden of …
tuberculosis (Mtb) infection are desperately needed to tackle the continuing global burden of …
A highly efficient way to recycle inactive stereoisomers of Bedaquiline into two previous intermediates via base-catalyzed Csp3Csp3 bond cleavage
DL Kong, Y Huang, LY Ren, WH Feng - Chinese Chemical Letters, 2015 - Elsevier
Bedaquiline is a new medicine for pulmonary multi-drug resistant tuberculosis (MDR-TB),
which is a pure enantiomer with two chiral centers. The current industrial preparation …
which is a pure enantiomer with two chiral centers. The current industrial preparation …
贝达喹啉治疗耐多药结核病安全性与有效性的系统评价.
牛瑞青， 于珊珊， 付萌萌， 刘丽萍… - Evaluation & Analysis …, 2018 - search.ebscohost.com
摘要目的: 评价贝达喹啉治疗耐多药结核病的疗效与安全性. 方法: 计算机检索PubMed,
EMBase, the Cochrane Library, 维普数据库, 中国期刊全文数据库及万方数据库 …
EMBase, the Cochrane Library, 维普数据库, 中国期刊全文数据库及万方数据库 …
Design, synthesis and biological evaluation of anti-tuberculosis agents based on bedaquiline structure
C Wu, J Luo, M Wu, F Meng, Z Cai, Y Chen… - Medicinal …, 2020 - ingentaconnect.com
Background: Bedaquiline is a novel anti-tuberculosis drug that inhibits Mycobacterial ATP
synthase. However, studies have found that bedaquiline has serious side effects due to high …
synthase. However, studies have found that bedaquiline has serious side effects due to high …