Hemoglobin (Hb) plays its vital role through structural and functional properties
evolutionarily optimized to work within red blood cells, ie, the tetrameric assembly, well …

Hemoglobin (Hb) is the major oxygen (O2)-carrying system of the blood but has many
potentially dangerous side effects due to oxidation and reduction reactions of the heme …

While the effectiveness of PEGylation in enhancing the stability and potency of protein
pharmaceuticals has been validated for years, the underlying mechanism remains poorly …

The development of oxygen (O 2)-carrying blood substitutes has evolved from the goal of
replicating blood O 2 transport properties to that of preserving microvascular and organ …

It has been 20 years since the publication of Chemistry of Protein Conjugation and Cross-
Linking. During this period, great advances have been made in the area of cross-linking of …

Significance: Despite many advances in blood substitute research, the development of
materials that are effective in maintaining blood volume and oxygen delivery remains a …

Covalent attachment of poly (ethylene) glycol (PEG) groups to proteins, a process commonly
called PEGylation, is often used to improve the performance of a protein in vivo. To date, at …

In routine clinical procedures, blood transfusion is now suffering from the defects of the
blood products, like cross‐matching, short storage time and virus infection. Various blood …

Nitrite was once thought to have little physiological relevance. However, nitrite is now being
increasingly recognized as a therapeutic or possibly even physiological precursor of nitric …

Red cells are the oxygen-carrying components of blood. In modern medical practice,
transfusions are given as suspensions of type-matched red cells in saline to replace lost …