Extrapulmonary manifestations of COVID-19 have gained attention due to their links to
clinical outcomes and their potential long-term sequelae. Severe acute respiratory syndrome …

T-cell exhaustion denotes a hypofunctional state of T lymphocytes commonly found in
cancer, but how tumor cells drive T-cell exhaustion remains elusive. Here, we find T-cell …

Background & Aims Chronic hepatitis C virus (HCV) infection is an important risk factor for
hepatocellular carcinoma (HCC). Despite effective antiviral therapies, the risk for HCC is …

The hepatitis C virus (HCV) is responsible for approximately 50 million infections worldwide.
Effective drug treatments while available face access barriers, and vaccine development is …

Chronic viral hepatitis infections, caused by the hepatitis B or C virus, are a major global
health problem causing an estimated one million deaths each year. Immunological studies …

Background Recent genome-wide association studies (GWASs) have revealed the
polygenic nature of psychiatric disorders and discovered a few of single-nucleotide …

Chronic liver disease and hepatocellular carcinoma (HCC) are life-threatening diseases
with limited treatment options. The lack of clinically relevant/tractable experimental models …

Objective Hepatocellular carcinoma (HCC) is the fastest-growing cause of cancer-related
mortality with chronic viral hepatitis and non-alcoholic steatohepatitis (NASH) as major …

Chronic liver disease and cancer are global health challenges. The role of the circadian
clock as a regulator of liver physiology and disease is well established in rodents, however …

Background & Aims Hepatitis C virus (HCV) infections most often result in chronic outcomes,
although the virus constantly produces replication intermediates, in particular double …