Type V protein secretion pathway: the autotransporter story

IR Henderson, F Navarro-Garcia… - Microbiology and …, 2004 - Am Soc Microbiol
Gram-negative bacteria possess an outer membrane layer which constrains uptake and
secretion of solutes and polypeptides. To overcome this barrier, bacteria have developed …

Epidemiology and clinical manifestations of enteroaggregative Escherichia coli

B Hebbelstrup Jensen, KEP Olsen… - Clinical microbiology …, 2014 - Am Soc Microbiol
Enteroaggregative Escherichia coli (EAEC) represents a heterogeneous group of E. coli
strains. The pathogenicity and clinical relevance of these bacteria are still controversial. In …

Virulence functions of autotransporter proteins

IR Henderson, JP Nataro - Infection and immunity, 2001 - Am Soc Microbiol
Bacterial pathogens must execute a prodigious array of complex functions in order to
survive, multiply, and disseminate within mammalian hosts. Virulence determinants are …

From self sufficiency to dependence: mechanisms and factors important for autotransporter biogenesis

DL Leyton, AE Rossiter, IR Henderson - Nature Reviews Microbiology, 2012 - nature.com
Autotransporters are a superfamily of proteins that use the type V secretion pathway for their
delivery to the surface of Gram-negative bacteria. At first glance, autotransporters look to …

Sat, the Secreted Autotransporter Toxin of Uropathogenic Escherichia coli, Is a Vacuolating Cytotoxin for Bladder and Kidney Epithelial Cells

DM Guyer, S Radulovic, FE Jones… - Infection and …, 2002 - Am Soc Microbiol
The secreted autotransporter toxin (Sat) of uropathogenic Escherichia coli exhibits
cytopathic activity upon incubation with HEp-2 cells. We further investigated the effects of Sat …

Enteroaggregative Escherichia coli

JP Nataro - Emerging infections 6, 2004 - Wiley Online Library
The first reported outbreak of Enteroaggregative Escherichia coli (EAEC) diarrhea occurred
in Serbia, where 19 newborns in a nursery developed watery diarrhea. Recently, EAEC has …

Bacterial serine proteases secreted by the autotransporter pathway: classification, specificity, and role in virulence

F Ruiz-Perez, JP Nataro - Cellular and molecular life sciences, 2014 - Springer
Serine proteases exist in eukaryotic and prokaryotic organisms and have emerged during
evolution as the most abundant and functionally diverse group. In Gram-negative bacteria …

Proteomic and microarray characterization of the AggR regulon identifies a pheU pathogenicity island in enteroaggregative Escherichia coli

EG Dudley, NR Thomson, J Parkhill… - Molecular …, 2006 - Wiley Online Library
Enteroaggregative Escherichia coli (EAEC) is defined by aggregative adherence (AA) to
HEp‐2 cells, where bacteria display adherence to cell surfaces and also to the intervening …

Identification of Sat, an autotransporter toxin produced by uropathogenic Escherichia coli

DM Guyer, IR Henderson, JP Nataro… - Molecular …, 2000 - Wiley Online Library
Urinary tract infection (UTI) is a very common extraintestinal infection, and Escherichia coli is
by far the most common causative organism. Uropathogenic E. coli possess traits that …

A review of an emerging enteric pathogen: enteroaggregative Escherichia coli

DB Huang, A Mohanty, HL DuPont… - Journal of medical …, 2006 - microbiologyresearch.org
Enteroaggregative Escherichia coli (EAEC) is an increasingly recognized enteric pathogen.
It is a cause of both acute and persistent diarrhoea among children, adults and HIV-infected …