AlphaFold2 and its applications in the fields of biology and medicine
Z Yang, X Zeng, Y Zhao, R Chen - Signal Transduction and Targeted …, 2023 - nature.com
Abstract AlphaFold2 (AF2) is an artificial intelligence (AI) system developed by DeepMind
that can predict three-dimensional (3D) structures of proteins from amino acid sequences …
that can predict three-dimensional (3D) structures of proteins from amino acid sequences …
Protein assembly by design
Proteins are nature's primary building blocks for the construction of sophisticated molecular
machines and dynamic materials, ranging from protein complexes such as photosystem II …
machines and dynamic materials, ranging from protein complexes such as photosystem II …
Hydrogen-bonded organic framework biomimetic entrapment allowing non-native biocatalytic activity in enzyme
G Chen, L Tong, S Huang, S Huang, F Zhu… - Nature …, 2022 - nature.com
Nature programs the structural folding of an enzyme that allows its on-demand
biofunctionality; however, it is still a long-standing challenge to manually modulate an …
biofunctionality; however, it is still a long-standing challenge to manually modulate an …
Tau post-translational modifications: dynamic transformers of tau function, degradation, and aggregation
C Alquezar, S Arya, AW Kao - Frontiers in neurology, 2021 - frontiersin.org
Post-translational modifications (PTMs) on tau have long been recognized as affecting
protein function and contributing to neurodegeneration. The explosion of information on …
protein function and contributing to neurodegeneration. The explosion of information on …
AlphaFold, artificial intelligence (AI), and allostery
R Nussinov, M Zhang, Y Liu, H Jang - The Journal of Physical …, 2022 - ACS Publications
AlphaFold has burst into our lives. A powerful algorithm that underscores the strength of
biological sequence data and artificial intelligence (AI). AlphaFold has appended projects …
biological sequence data and artificial intelligence (AI). AlphaFold has appended projects …
Targeted protein degradation: elements of PROTAC design
SL Paiva, CM Crews - Current opinion in chemical biology, 2019 - Elsevier
Targeted protein degradation using Proteolysis Targeting Chimeras (PROTACs) has
emerged as a novel therapeutic modality in drug discovery. PROTACs mediate the …
emerged as a novel therapeutic modality in drug discovery. PROTACs mediate the …
Design, fabrication and control of origami robots
Origami robots are created using folding processes, which provide a simple approach to
fabricating a wide range of robot morphologies. Inspired by biological systems, engineers …
fabricating a wide range of robot morphologies. Inspired by biological systems, engineers …
Supramolecular helical systems: helical assemblies of small molecules, foldamers, and polymers with chiral amplification and their functions
E Yashima, N Ousaka, D Taura, K Shimomura… - Chemical …, 2016 - ACS Publications
In this review, we describe the recent advances in supramolecular helical assemblies
formed from chiral and achiral small molecules, oligomers (foldamers), and helical and …
formed from chiral and achiral small molecules, oligomers (foldamers), and helical and …
Protein misfolding, amyloid formation, and human disease: a summary of progress over the last decade
Peptides and proteins have been found to possess an inherent tendency to convert from
their native functional states into intractable amyloid aggregates. This phenomenon is …
their native functional states into intractable amyloid aggregates. This phenomenon is …
Dynamics of oligomer populations formed during the aggregation of Alzheimer's Aβ42 peptide
Oligomeric species populated during the aggregation of the Aβ42 peptide have been
identified as potent cytotoxins linked to Alzheimer's disease, but the fundamental molecular …
identified as potent cytotoxins linked to Alzheimer's disease, but the fundamental molecular …