The chloride importer NKCC1 and the chloride exporter KCC2 are key regulators of
neuronal chloride concentration. A defective NKCC1/KCC2 expression ratio is associated …

The sudden loss of movement after spinal cord injury (SCI) is life-changing and is a major
impetus to study spinal cord motor system plasticity and devise novel repair strategies. This …

Spinal cord injury (SCI) often results in spasticity. There is currently no effective therapy for
spasticity. Here, we describe a method to efficiently differentiate human pluripotent stem …

Non-invasive brain stimulation techniques have been exploited in motor neuron disease
(MND) with multifold objectives: to support the diagnosis, to get insights in the …

Despite the frequency of spasticity, robust diagnostic criteria and reliable assessment scales
are required. High-quality studies are needed to support the efficacy of current treatments for …

The review surveys various aspects of the plasticity of nerve fibers, in particular the
prolonged increase in their excitability evoked by polarization, focusing on a long-lasting …

Clinical findings suggest that transcutaneous spinal direct current stimulation (tsDCS) can
modulate ascending sensitive, descending corticospinal, and segmental pathways in the …

Although spasticity is one of the most common causes of motor disability worldwide, its
precise definition and pathophysiology remain elusive, which to date renders its …

Transcutaneous spinal cord stimulation (tSCS) as a neuromodulatory strategy has received
great attention as a method to promote functional recovery after spinal cord injury (SCI) …

Correct operation of neuronal networks depends on the interplay between synaptic
excitation and inhibition processes leading to a dynamic state termed balanced network. In …