Prefrontal cortex and depression

DA Pizzagalli, AC Roberts - Neuropsychopharmacology, 2022 - nature.com
The prefrontal cortex (PFC) has emerged as one of the regions most consistently impaired in
major depressive disorder (MDD). Although functional and structural PFC abnormalities …

Emotion, motivation, decision-making, the orbitofrontal cortex, anterior cingulate cortex, and the amygdala

ET Rolls - Brain Structure and Function, 2023 - Springer
The orbitofrontal cortex and amygdala are involved in emotion and in motivation, but the
relationship between these functions performed by these brain structures is not clear. To …

The hippocampus, ventromedial prefrontal cortex, and episodic and semantic memory

ET Rolls - Progress in Neurobiology, 2022 - Elsevier
The human ventromedial prefrontal cortex (vmPFC)/anterior cingulate cortex is implicated in
reward and emotion, but also in memory. It is shown how the human orbitofrontal cortex …

The human orbitofrontal cortex, vmPFC, and anterior cingulate cortex effective connectome: emotion, memory, and action

ET Rolls, G Deco, CC Huang, J Feng - Cerebral cortex, 2023 - academic.oup.com
The human orbitofrontal cortex, ventromedial prefrontal cortex (vmPFC), and anterior
cingulate cortex are involved in reward processing and thereby in emotion but are also …

Hippocampal spatial view cells for memory and navigation, and their underlying connectivity in humans

ET Rolls - Hippocampus, 2023 - Wiley Online Library
Hippocampal and parahippocampal gyrus spatial view neurons in primates respond to the
spatial location being looked at. The representation is allocentric, in that the responses are …

[HTML][HTML] The human language effective connectome

ET Rolls, G Deco, CC Huang, J Feng - NeuroImage, 2022 - Elsevier
To advance understanding of brain networks involved in language, the effective connectivity
between 26 cortical regions implicated in language by a community analysis and 360 …

Human amygdala compared to orbitofrontal cortex connectivity, and emotion

ET Rolls, G Deco, CC Huang, J Feng - Progress in Neurobiology, 2023 - Elsevier
The amygdala and orbitofrontal cortex have been implicated in emotion. To understand
these regions better in humans, their effective connectivity with 360 cortical regions was …

Roles of the medial and lateral orbitofrontal cortex in major depression and its treatment

B Zhang, ET Rolls, X Wang, C Xie, W Cheng… - Molecular …, 2024 - nature.com
We describe evidence for dissociable roles of the medial and lateral orbitofrontal cortex
(OFC) in major depressive disorder (MDD) from structure, functional activation, functional …

Rewiring of the serotonin system in major depression

F Vahid-Ansari, PR Albert - Frontiers in psychiatry, 2021 - frontiersin.org
Serotonin is a key neurotransmitter that is implicated in a wide variety of behavioral and
cognitive phenotypes. Originating in the raphe nuclei, 5-HT neurons project widely to …

The effective connectivity of the human hippocampal memory system

ET Rolls, G Deco, CC Huang, J Feng - Cerebral Cortex, 2022 - academic.oup.com
Effective connectivity measurements in the human hippocampal memory system based on
the resting-state blood oxygenation-level dependent signal were made in 172 participants in …