2-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2
Prolyl hydroxylation of hypoxia inducible factor (HIF)-α, as catalysed by the Fe (II)/2-
oxoglutarate (2OG)-dependent prolyl hydroxylase domain (PHD) enzymes, has a hypoxia …
oxoglutarate (2OG)-dependent prolyl hydroxylase domain (PHD) enzymes, has a hypoxia …
Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal Trichoplax adhaerens
K Lippl, A Boleininger, MA McDonough, MI Abboud… - Hypoxia, 2018 - Taylor & Francis
Background: In humans and other animals, the chronic hypoxic response is mediated by
hypoxia inducible transcription factors (HIFs) which regulate the expression of genes that …
hypoxia inducible transcription factors (HIFs) which regulate the expression of genes that …
Biophysical Characterization of Prolyl Hydroxylation-dependent HIF-1α Degradation
W He - 2024 - search.proquest.com
Metazoan life is dependent upon the utilization of O 2 for proper cellular metabolism and
energy production. Low levels of oxygen, or hypoxia, at the tissue level can occur due to …
energy production. Low levels of oxygen, or hypoxia, at the tissue level can occur due to …
Mechanistic insight into oxygen diffusion in prolyl hydroxylase domain-2 by equilibrium and non-equilibrium, classical and ab initio molecular dynamics simulations
C Domene, C Jorgensen - fig.if.usp.br
The human oxygen sensing cycle characterizes the physiological regulation and detection
of oxygen levels in mammals. It is now well-established that a relationship between the …
of oxygen levels in mammals. It is now well-established that a relationship between the …