Though the history of mankind, we are strongly fighting with infected diseases that are
induced by bacteria, fungi, viruses, and other pathogens. Although a variety of medicines …

The advances in the field of biomaterials have led to several studies on alternative
biocompatible devices and to their development focusing on their properties, benefits …

Ocular diseases may be treated via different routes of administration, such as topical,
intracameral, intravitreal, oral and parenteral. Among them the topical route is most accepted …

This review focuses on two formulation approaches, mucoadhesion and thermogelling,
intended for prolonging residence time on vaginal mucosa of medical devices or drug …

Aqueous gels formulated using hydrophilic polymers (hydrogels) along with those based on
stimuli responsive polymers (in situ gelling or gel forming systems) continue to attract …

Highlights•Poloxamers-based in situ gels are potential vehicles for ocular drug
delivery.•Poloxamers possess reversible thermoresponsive gelling and mucoadhesive …

The low therapeutic efficacy exhibited by conventional ophthalmic solutions owing to
precorneal elimination of the drug, drainage by gravity, nasolacrimal drainage, conjunctival …

Rapid clearance and low ocular bioavailability are drawbacks of conventional ophthalmic
eye drops. To increase the ocular drug resistance time and improve efficacy, an in situ …

The major complications associated with the administration of ocular dosage forms are the
precorneal loss due to the nasolacrimal drainage and high turnover of tear fluid. In situ …

In situ gels are systems which are applied as solutions or suspensions and are capable of
undergoing rapid sol-to-gel transformation triggered by external stimulus such as …