Abstract Trastuzumab deruxtecan (T-DXd; DS-8201) is an antibody-drug conjugate targeting
human epidermal growth factor receptor 2. Interstitial lung disease (ILD)/pneumonitis is an …

Numerous compounds have shown efficacy in limiting development of pulmonary fibrosis
using animal models, yet few of these compounds have replicated these beneficial effects in …

Persistence of Mycobacterium tuberculosis remains a significant challenge for the effective
treatment of tuberculosis in humans. In animals that develop necrotic lung lesions following …

Aims: In addition to nitric oxide and carbon monoxide, hydrogen sulfide (H2S) is an
endogenously synthesized gaseous molecule that acts as an important signaling molecule …

Background: The long-term use of opioids for analgesia carries significant risk for tolerance,
addiction, and diversion. These adverse effects are largely mediated by mu-opioid receptors …

Introduction Radiation-induced pneumonitis and fibrosis have restricted radiotherapy for
lung cancer. In a preclinical lung tumor model, soy isoflavones showed the potential to …

Arterial oxygen saturation has not been assessed sequentially in conscious mice as a direct
consequence of an in vivo murine model of acute lung injury. Here, we report daily changes …

Objectives: In many jurisdictions, ethical concerns require surrogate humane endpoints to
replace death in small animal models of acute lung injury. Heterogenous selection and …

Hypoxia-inducible factor 1 (HIF-1) is the main transcription factor responsible for hypoxia-
induced gene expression. Perioperative drugs including anesthetics have been reported to …

Abstract Platelet Endothelial Cell Adhesion Molecule 1 (PECAM-1) deficient mice in the
FVB/n strain exhibit fatal chronic pulmonary fibrotic disease. The illness occurs in the …