The existence of free radicals in living cells was first reported in 1954 and this important
finding helped launch the field of free radical biology. However, the discovery that muscular …

Skeletal muscle plasticity and its adaptation to exercise is a topic that is widely discussed
and investigated due to its primary role in the field of exercise performance and health …

Reactive oxygen species (ROS) act as intracellular compartmentalized second messengers,
mediating metabolic stress-adaptation. In skeletal muscle fibers, ROS have been suggested …

Age-related loss of skeletal muscle mass and function is a major contributor to morbidity and
has a profound effect on the quality of life of older people. The potential role of age …

Exercise redox biochemistry is of considerable interest owing to its translational value in
health and disease. However, unaddressed conceptual, methodological and technical …

The exogenous antioxidants vitamin C (ascorbate) and vitamin E (α-tocopherol) often blunt
favorable cell signaling responses to exercise, suggesting that redox signaling contributes to …

Osteopontin (OPN) is a multifunctional noncollagenous matrix phosphoprotein that is
expressed both intracellularly and extracellularly in various tissues. As a growth regulatory …

The field of redox biology is inherently intertwined with oxidative stress biomarkers.
Oxidative stress biomarkers have been utilized for many different objectives. Our analysis …

Protein S-glutathionylation is an important reversible post-translational modification
implicated in redox signaling. Oxidative modifications to protein thiols can alter the activity of …

Skeletal muscle homeostasis depends on an intricate balance between muscle hypertrophy,
atrophy and regeneration. As we age, maintenance of muscle homeostasis is perturbed …