Substitution of a hydrogen atom with its heavy isotope deuterium entails the addition of one
neutron to a molecule. Despite being a subtle change, this structural modification, known as …

GS-441524, an RNA‐dependent RNA polymerase (RdRp) inhibitor, is a 1′-CN-substituted
adenine C-nucleoside analog with broad-spectrum antiviral activity. However, the low oral …

Vertebrate vision critically depends on an 11-cis-retinoid renewal system known as the
visual cycle. At the heart of this metabolic pathway is an enzyme known as retinal pigment …

The review covers various aspects of fluorinated cycloalkyl (C3− C7) building blocks for drug
discovery, including their synthesis, key physicochemical properties, and biological and …

Property prediction is a key interest in chemistry. For several decades there has been a
continued and incremental development of mathematical models to predict properties. As …

Inherited retinal dystrophies (IRDs) are a large group of genetically and clinically
heterogeneous diseases characterized by the progressive degeneration of the retina …

The eye is an ideal organ for imaging by a multi-photon excitation approach, because ocular
tissues such as the sclera, cornea, lens and neurosensory retina, are highly transparent to …

The β-aminoketone moiety has been found to be the basic skeleton of several drugs such as
the amine salts “tolperisone (vasodilation)” and “oxyfedrine (therapeutic coronary disease)” …

A visible light-promoted radical relay of N-allylbromodifluoroacetamide with quinoxalin-2 (1
H)-ones was developed in which 5-exo-trig cyclization and C–C bond formation were …

Sulfur hexafluoride (SF6) is an artificial inert gas widely used in the power and
semiconductor industries and is known to be a significant contributor to the greenhouse …