Integrins are considered the main cell-adhesion transmembrane receptors that play
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …

Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease of the lung with poor
survival. The incidence and mortality of IPF are rising, but treatment remains limited …

Integrins are transmembrane receptors that possess distinct ligand-binding specificities in
the extracellular domain and signaling properties in the cytoplasmic domain. While most …

The collagen family contains 28 proteins, predominantly expressed in the extracellular
matrix (ECM) and characterized by a triple-helix structure. Collagens undergo several …

The ability of cells to sense and respond to changes in mechanical environment is vital in
conditions of organ injury when the architecture of normal tissues is disturbed or lost. Among …

Inhibitors of the transforming growth factor–β (TGF-β) pathway are potentially promising
antifibrotic therapies, but nonselective simultaneous inhibition of all three TGF-β homologs …

Abstract The RGD (Arg-Gly-Asp)-binding integrins αvβ6 and αvβ8 are clinically validated
cancer and fibrosis targets of considerable therapeutic importance. Compounds that can …

Rationale: Idiopathic pulmonary fibrosis (IPF) causes progressive lung scarring and high
mortality. Reliable and accurate prognostic biomarkers are urgently needed. Objectives: To …

Idiopathic pulmonary fibrosis (IPF) remains a disease with poor survival. The pathogenesis
is complex and encompasses multiple molecular pathways. The first-generation antifibrotics …

Rationale: Idiopathic pulmonary fibrosis (IPF) is a rare and progressive disease that causes
progressive cough, exertional dyspnea, impaired quality of life, and death. Objectives …