DNA damage processing by mismatch repair (MMR) and/or base excision repair (BER) can
determine the therapeutic index following treatment of human cancers using radiation …

DNA repair is a rapidly advancing field in biology and these systems represent a major
defense mechanism against environmental and intracellular damaging agents such as …

Concentration response experiments are utilized widely to characterize the response of
tumor cell lines to chemotherapeutic drugs, but the assay methods are non-standardized …

Update on radiosensitization by halogenated thymidine analogs-molecular mechanisms of drug
processing and cell death signaling: Page 1 [Cancer Biology & Therapy 7:10, 1567-1569; …

The term cancer, which is derived from the Greek word" karkinos", meaning crab,
encompasses over 100 distinct diseases that are characterized by an uncontrolled …

A more flexible and higher-yielding in vitro DNA mismatch repair (MMR) substrate
construction method, which was developed initially by Wang and Hays, is described for the …

Over the last 7 years, we have focused our experimental and computational research efforts
on improving our understanding of the biochemical, molecular, and cellular processing of …

DNA mismatch repair (MMR) is involved in processing DNA damage following treatment
with ionising radiation (IR) and various classes of chemotherapy drugs including …

In this study, we develop asynchronous probabilistic cell cycle models to quantitatively
assess the effect of ionizing radiation on a human colon cancer cell line. We use both …

Embryonic stem cells (ESC) are pluripotent cells derived from the inner cell mass of the
blastocyst. These cells have the unique properties of unlimited self-renewal and …