Many intriguing facets of lipoxygenase (LOX) catalysis are open to a detailed structural
analysis. Polyunsaturated fatty acids with two to six double bonds are oxygenated precisely …

Lipoxygenases (LOXs) have attracted a great deal of attention as potential starting
biocatalysts for synthesizing signaling compounds. Significant advances during the past …

Green leaf volatiles (GLVs) are mainly C6-and in rare cases also C9-aldehydes,-alcohols,
and-esters, which are released by plants in response to biotic or abiotic stresses. These …

Lipoxygenases (LOXs) are a key part of several signaling pathways that lead to
inflammation and cancer. Yet, the mechanisms of substrate binding and allosteric regulation …

Here, we describe the first systematic study on the mechanism of substrate-selective
inhibition of mammalian ALOX15 orthologs. For this purpose, we prepared a series of N …

Lipoxygenases (LOXs) are a family of enzymes that includes different fatty acid oxygenases
with a common tridimensional structure. The main functions of LOXs are the production of …

Alzheimer's disease (AD) is characterized by the progressive disturbance in cognition and
affects approximately 36 million people, worldwide. However, the drugs used to treat this …

Mammalian lipoxygenases (LOXs) have been implicated in cellular defense response and
are important for physiological homeostasis. Since their discovery, LOXs have been …

Eicosanoids are inflammatory signaling lipids that are biosynthesized in response to cellular
injury or threat. They were originally thought to be pro-inflammatory molecules, but members …

Lipoxygenases (LOX) are a family lipid oxygenating enzymes that can generate bioactive
lipids of clinical relevance from polyunsaturated fatty acids. Most LOXs display a Ca 2+ …