Sex differences in lipid metabolism: implications for systemic lupus erythematosus and cardiovascular disease risk

GA Robinson, I Pineda-Torra, C Ciurtin… - Frontiers in Medicine, 2022 - frontiersin.org
It is known that healthy women during childbearing years have a lower risk of cardiovascular
disease (CVD) and coronary heart disease compared to age matched men. Various …

Impact of puberty, sex determinants and chronic inflammation on cardiovascular risk in young people

A Allalou, J Peng, GA Robinson… - Frontiers in …, 2023 - frontiersin.org
Worrying trends of increased cardiovascular disease (CVD) risk in children, adolescents and
young people in the Modern Era have channelled research and public health strategies to …

Atherosclerosis Progression in the APPLE Trial Can Be Predicted in Young People With Juvenile‐Onset Systemic Lupus Erythematosus Using a Novel Lipid …

J Peng, P Dönnes, SP Ardoin… - Arthritis & …, 2024 - Wiley Online Library
Objective Patients with juvenile‐onset systemic lupus erythematosus (JSLE) have increased
atherosclerosis risk. This study investigated novel atherosclerosis progression biomarkers in …

Systemic lupus erythematosus patients have unique changes in serum metabolic profiles across age associated with cardiometabolic risk

EC Jury, J Peng, A Van Vijfeijken… - …, 2024 - academic.oup.com
Objectives Cardiovascular disease through accelerated atherosclerosis is a leading cause
of mortality for patients with systemic lupus erythematosus (SLE), likely due to increased …

AIM2 inflammasome regulated by the IFN‐γ/JAK2/STAT1 pathway promotes activation and pyroptosis of monocytes in Coronary Artery Disease

Y Zhao, B Liang, S Sheng, C Wang… - Immunity …, 2024 - Wiley Online Library
Background Numerous studies have demonstrated that Absent in Melanoma 2 (AIM2) is
upregulated in aortic plaques, especially in Vascular Smooth Muscle Cells in Coronary …

Role of Lipoprotein Levels and Function in Atherosclerosis Associated with Autoimmune Rheumatic Diseases

N Ronda, F Zimetti, MP Adorni… - Rheumatic …, 2023 - rheumatic.theclinics.com
As in the general population, atherosclerosis (ATH) in autoimmune rheumatic diseases
(ARDs) is due to the contribution of several factors including lifestyle, hypertension, local …

Cardiovascular risk in young people with childhood onset systemic lupus erythematosus

C Ciurtin, G Robinson, M Butt, J Peng… - The Lancet …, 2024 - thelancet.com
Since 1940, epidemiologists, clinicians, and scientists promoted increased awareness of the
crucial importance of promoting preventive strategies for minimising the risk of poor health …

Subclinical atherosclerosis risk can be predicted in females with systemic lupus erythematosus (SLE) using metabolomic signatures

L Woodridge, M Tektonidou, GA Robinson… - Available at SSRN …, 2024 - papers.ssrn.com
Background: Cardiovascular disease (CVD) is a leading cause of mortality in people with
systemic lupus erythematosus (SLE) yet established clinical scores fail to predict CVD-risk …

Investigation of the performance of validated cardiovascular risk scores in a global (UK/US) cohort of young people with childhood-onset systemic lupus …

C Ciurtin, J Peng, Y Gao, M Niwa, SP Ardoin… - Lupus Science & …, 2024 - lupus.bmj.com
Presented as Oral Presentation at the 14th European Lupus Meeting 2024, Brugge and
published online-Gao Y, Niwa M, Peng J, et al. O26 First investigation of the performance of …

Additional Analysis of the APPLE (Atherosclerosis Prevention in Paediatric Lupus Erythematosus) Trial Identifies Novel Determinants of Patient Heterogeneity and a …

J Peng, P Donnes, S Ardoin… - Preprints with THE …, 2023 - discovery.ucl.ac.uk
Background: Juvenile-onset systemic lupus erythematosus (JSLE) is associated with chronic
inflammation and increased risk of atherosclerosis. The APPLE trial was a randomised …