The use of deuteration in medicinal chemistry has exploded in the past years, and the FDA
has recently approved the first deuterium-labeled drug. Precision deuteration goes beyond …

Mitochondrial dysfunction is reiteratively involved in the pathogenesis of diverse
neurodegenerative diseases. Current in vitro and in vivo approaches support that …

Background and Objectives The understanding of the natural history of Friedreich ataxia
(FRDA) has improved considerably recently, but patterns of neurologic deterioration are not …

The cerebellum is a key player in many brain functions and a major topic of neuroscience
research. However, the cerebellar nuclei (CN), the main output structures of the cerebellum …

Cerebellar and afferent ataxias present with a characteristic gait disorder that reflects
cerebellar motor dysfunction and sensory loss. These disorders are a diagnostic challenge …

Hepcidin is emerging as a new important factor in brain iron homeostasis. Studies suggest
that there are two sources of hepcidin in the brain; one is local and the other comes from the …

Friedreich ataxia (FA) is a rare mitochondrial disease characterized by sensory and
spinocerebellar ataxia, hypertrophic cardiomyopathy, and diabetes, for which there is no …

Background Exercise is considered as an important intervention for treatment and
prevention of several diseases, such as osteoarthritis, obesity, hypertension, and …

In cancer classification, gene selection is an important data preprocessing technique, but it
is a difficult task due to the large search space. Accordingly, the objective of this study is to …

Background Neuroinflammation is proposed to accompany, or even contribute to,
neuropathology in Friedreich ataxia (FRDA), with implications for disease treatment and …